Burn the house, save the day: pyroptosis in pathogen restriction

Boucher, Dave, Chen, Kaiwen W. and Schroder, Kate (2015) Burn the house, save the day: pyroptosis in pathogen restriction. Inflammasome, 2 1: . doi:10.1515/infl-2015-0001

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Author Boucher, Dave
Chen, Kaiwen W.
Schroder, Kate
Title Burn the house, save the day: pyroptosis in pathogen restriction
Journal name Inflammasome   Check publisher's open access policy
ISSN 2300-102X
Publication date 2015-01
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1515/infl-2015-0001
Open Access Status DOI
Volume 2
Issue 1
Total pages 6
Place of publication Warsaw, Poland
Publisher De Gruyter Open
Collection year 2016
Language eng
Formatted abstract
Many programmed cell death pathways are essential for organogenesis, development, immunity and the maintenance of homeostasis in multicellular organisms. Pyroptosis, a highly proinflammatory form of cell death, is a critical innate immune response to prevent intracellular infection. Pyroptosis is induced upon the activation of proinflammatory caspases within macromolecular signalling platforms called inflammasomes. This article reviews our understanding of pyroptosis induction, the function of inflammatory caspases in pyroptosis execution, and the importance of pyroptosis for pathogen clearance. It also highlights the situations in which extensive pyroptosis may in fact be detrimental to the host, leading to immune cell depletion or cytokine storm. Current efforts to understand the beneficial and pathological roles of pyroptosis bring the promise of new approaches to fight infectious diseases.
Keyword Pyroptosis
Caspase
Inflammasomes
Pathogen restriction
Immune evasion
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
Institute for Molecular Bioscience - Publications
 
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Created: Fri, 27 Mar 2015, 11:49:18 EST by Dave Boucher on behalf of Institute for Molecular Bioscience