Production and packaging of a biological arsenal: evolution of centipede venoms under morphological constraint

Undheim, Eivind A.B., Hamilton, Brett R., Kurniawan, Nyoman D., Bowlay, Greg, Cribb, Bronwen W., Merritt, David J., Fry,Bryan G., King, Glenn F and Venter, Deon J. (2015) Production and packaging of a biological arsenal: evolution of centipede venoms under morphological constraint. PNAS: Proceedings of the National Academy of Sciences of the United States of America, 112 13: 4026-4031. doi:10.1073/pnas.1424068112


Author Undheim, Eivind A.B.
Hamilton, Brett R.
Kurniawan, Nyoman D.
Bowlay, Greg
Cribb, Bronwen W.
Merritt, David J.
Fry,Bryan G.
King, Glenn F
Venter, Deon J.
Title Production and packaging of a biological arsenal: evolution of centipede venoms under morphological constraint
Journal name PNAS: Proceedings of the National Academy of Sciences of the United States of America   Check publisher's open access policy
ISSN 1091-6490
0027-8424
Publication date 2015-03-31
Year available 2015
Sub-type Article (original research)
DOI 10.1073/pnas.1424068112
Volume 112
Issue 13
Start page 4026
End page 4031
Total pages 6
Place of publication Washington, DC United States
Publisher National Academy of Sciences
Collection year 2016
Language eng
Abstract Venom peptides have attracted considerable attention because of their value as pharmacological tools and their potential for development as novel pharmaceuticals and bioinsecticides. There is also a growing interest in venoms as model evolutionary systems, particularly for understanding antagonistic coevolutionary processes. We previously demonstrated that although centipede venoms are rich in novel proteins and peptides, there are considerable differences in venom complexity between high-order taxa. We show that this disparity appears to stem from morphological limitations of the venom gland, and that most centipede venoms likely evolve under constraints imposed by low-complexity toxin production facilities. Thus, the centipede venom apparatus should be a useful model system for gaining insight into the impact of morphological constraints on venom evolution.
Keyword Venom evolution
Venom-gland morphology
Centipede
Mass spectrometry imaging
Venom optimization hypothesis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Thu, 26 Mar 2015, 14:32:12 EST by Susan Allen on behalf of Institute for Molecular Bioscience