Genome-wide association study of endometrial cancer in E2C2

De Vivo, Immaculata, Prescott, Jennifer, Setiawan, Veronica Wendy, Olson, Sara H., Wentzensen, Nicolas, Attia, John, Black, Amanda, Brinton, Louise, Chen, Chu, Chen, Constance, Cook, Linda S., Crous-Bou, Marta, Doherty, Jennifer, Dunning, Alison M., Easton, Douglas F., Friedenreich, Christine M., Garcia-Closas, Montserrat, Gaudet, Mia M., Haiman, Christopher, Hankinson, Susan E., Hartge, Patricia, Henderson, Brian E., Holliday, Elizabeth, Horn-Ross, Pamela L., Hunter, David J., Le Marchand, Loic, Liang, Xiaolin, Lissowska, Jolanta, Long, Jirong, Lu, Lingeng, Magliocco, Anthony M., McEvoy, Mark, O'Mara, Tracy A., Orlow, Irene, Painter, Jodie N., Pooler, Loreall, Rastogi, Radhai, Rebbeck, Timothy R., Risch, Harvey, Sacerdote, Carlotta, Schumacher, Fredrick, Scott, Rodney J., Sheng, Xin, Shu, Xiao-ou, Spurdle, Amanda B., Thompson, Deborah, VanDen Berg, David, Weiss, Noel S., Xia, Lucy, Xiang, Yong-Bing, Yang, Hannah P., Yu, Herbert, Zheng, Wei, Chanock, Stephen and Kraft, Peter (2014) Genome-wide association study of endometrial cancer in E2C2. Human Genetics, 133 2: 211-224. doi:10.1007/s00439-013-1369-1

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Author De Vivo, Immaculata
Prescott, Jennifer
Setiawan, Veronica Wendy
Olson, Sara H.
Wentzensen, Nicolas
Attia, John
Black, Amanda
Brinton, Louise
Chen, Chu
Chen, Constance
Cook, Linda S.
Crous-Bou, Marta
Doherty, Jennifer
Dunning, Alison M.
Easton, Douglas F.
Friedenreich, Christine M.
Garcia-Closas, Montserrat
Gaudet, Mia M.
Haiman, Christopher
Hankinson, Susan E.
Hartge, Patricia
Henderson, Brian E.
Holliday, Elizabeth
Horn-Ross, Pamela L.
Hunter, David J.
Le Marchand, Loic
Liang, Xiaolin
Lissowska, Jolanta
Long, Jirong
Lu, Lingeng
Magliocco, Anthony M.
McEvoy, Mark
O'Mara, Tracy A.
Orlow, Irene
Painter, Jodie N.
Pooler, Loreall
Rastogi, Radhai
Rebbeck, Timothy R.
Risch, Harvey
Sacerdote, Carlotta
Schumacher, Fredrick
Scott, Rodney J.
Sheng, Xin
Shu, Xiao-ou
Spurdle, Amanda B.
Thompson, Deborah
VanDen Berg, David
Weiss, Noel S.
Xia, Lucy
Xiang, Yong-Bing
Yang, Hannah P.
Yu, Herbert
Zheng, Wei
Chanock, Stephen
Kraft, Peter
Title Genome-wide association study of endometrial cancer in E2C2
Journal name Human Genetics   Check publisher's open access policy
ISSN 0340-6717
Publication date 2014
Sub-type Article (original research)
DOI 10.1007/s00439-013-1369-1
Open Access Status
Volume 133
Issue 2
Start page 211
End page 224
Total pages 14
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2015
Language eng
Subject 2716 Genetics (clinical)
1311 Genetics
Abstract Endometrial cancer (EC), a neoplasm of the uterine epithelial lining, is the most common gynecological malignancy in developed countries and the fourth most common cancer among US women. Women with a family history of EC have an increased risk for the disease, suggesting that inherited genetic factors play a role. We conducted a two-stage genome-wide association study of Type I EC. Stage 1 included 5,472 women (2,695 cases and 2,777 controls) of European ancestry from seven studies. We selected independent single-nucleotide polymorphisms (SNPs) that displayed the most significant associations with EC in Stage 1 for replication among 17,948 women (4,382 cases and 13,566 controls) in a multiethnic population (African America, Asian, Latina, Hawaiian and European ancestry), from nine studies. Although no novel variants reached genome-wide significance, we replicated previously identified associations with genetic markers near the HNF1B locus. Our findings suggest that larger studies with specific tumor classification are necessary to identify novel genetic polymorphisms associated with EC susceptibility.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 14 times in Scopus Article | Citations
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Created: Thu, 26 Mar 2015, 14:07:47 EST by Matthew Lamb on behalf of School of Medicine