2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy

Li, Jingmei, Lindstroem, Linda S., Foo, Jia N., Rafiq, Sajjad, Schmidt, Marjanka K., Pharoah, Paul D. P., Michailidou, Kyriaki, Dennis, Joe, Bolla, Manjeet K., Wang, Qin, Van't Veer, Laura J., Cornelissen, Sten, Rutgers, Emiel, Southey, Melissa C., Apicella, Carmel, Dite, Gillian S., Hopper, John L., Fasching, Peter A., Haeberle, Lothar, Ekici, Arif B., Beckmann, Matthias W., Blomqvist, Carl, Muranen, Taru A., Aittomaeki, Kristiina, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kosma, Veli-Matti, Hartikainen, Jaana M., Kataja, Vesa, Chenevix-Trench, Georgia, Phillips, Kelly-Anne, McLachlan, Sue-Anne, Lambrechts, Diether, Thienpont, Bernard, Smeets, Ann, Wildiers, Hans, Chang-Claude, Jenny, Flesch-Janys, Dieter, Seibold, Petra, Rudolph, Anja, Giles, Graham G., Baglietto, Laura, Severi, Gianluca, Haiman, Christopher A., Henderson, Brian E., Schumacher, Fredrick, Le Marchand, Loic, Kristensen, Vessela, Alnaes, Grethe I. Grenaker, Borresen-Dale, Anne-Lise, Nord, Silje, Winqvist, Robert, Pylkas, Katri, Jukkola-Vuorinen, Arja, Grip, Mervi, Andrulis, Irene L., Knight, Julia A., Glendon, Gord, Tchatchou, Sandrine, Devilee, Peter, Tollenaar, Robert, Seynaeve, Caroline, Hooning, Maartje, Kriege, Mieke, Hollestelle, Antoinette, Van den Ouweland, Ans, Li, Yi, Hamann, Ute, Torres, Diana, Ulmer, Hans U., Rudiger, Thomas, Shen, Chen-Yang, Hsiung, Chia-Ni, Wu, Pei-Ei, Chen, Shou-Tung, Teo, Soo Hwang, Taib, Nur Aishah Mohd, Yip, Cheng Har, Ho, Gwo Fuang, Matsuo, Keitaro, Ito, Hidemi, Iwata, Hiroji, Tajima, Kazuo, Kang, Daehee, Choi, Ji-Yeob, Park, Sue K., Yoo, Keun-Young, Maishman, Tom, Tapper, William J., Dunning, Alison, Shah, Mitul, Luben, Robert, Brown, Judith, Khor, Chiea Chuen, Eccles, Diana M., Nevanlinna, Heli, Easton, Douglas, Humphreys, Keith, Liu, Jianjun, Hall, Per and Czene, Kamila (2014) 2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy. Nature Communications, 5 1-9. doi:10.1038/ncomms5051

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Author Li, Jingmei
Lindstroem, Linda S.
Foo, Jia N.
Rafiq, Sajjad
Schmidt, Marjanka K.
Pharoah, Paul D. P.
Michailidou, Kyriaki
Dennis, Joe
Bolla, Manjeet K.
Wang, Qin
Van't Veer, Laura J.
Cornelissen, Sten
Rutgers, Emiel
Southey, Melissa C.
Apicella, Carmel
Dite, Gillian S.
Hopper, John L.
Fasching, Peter A.
Haeberle, Lothar
Ekici, Arif B.
Beckmann, Matthias W.
Blomqvist, Carl
Muranen, Taru A.
Aittomaeki, Kristiina
Lindblom, Annika
Margolin, Sara
Mannermaa, Arto
Kosma, Veli-Matti
Hartikainen, Jaana M.
Kataja, Vesa
Chenevix-Trench, Georgia
Phillips, Kelly-Anne
McLachlan, Sue-Anne
Lambrechts, Diether
Thienpont, Bernard
Smeets, Ann
Wildiers, Hans
Chang-Claude, Jenny
Flesch-Janys, Dieter
Seibold, Petra
Rudolph, Anja
Giles, Graham G.
Baglietto, Laura
Severi, Gianluca
Haiman, Christopher A.
Henderson, Brian E.
Schumacher, Fredrick
Le Marchand, Loic
Kristensen, Vessela
Alnaes, Grethe I. Grenaker
Borresen-Dale, Anne-Lise
Nord, Silje
Winqvist, Robert
Pylkas, Katri
Jukkola-Vuorinen, Arja
Grip, Mervi
Andrulis, Irene L.
Knight, Julia A.
Glendon, Gord
Tchatchou, Sandrine
Devilee, Peter
Tollenaar, Robert
Seynaeve, Caroline
Hooning, Maartje
Kriege, Mieke
Hollestelle, Antoinette
Van den Ouweland, Ans
Li, Yi
Hamann, Ute
Torres, Diana
Ulmer, Hans U.
Rudiger, Thomas
Shen, Chen-Yang
Hsiung, Chia-Ni
Wu, Pei-Ei
Chen, Shou-Tung
Teo, Soo Hwang
Taib, Nur Aishah Mohd
Yip, Cheng Har
Ho, Gwo Fuang
Matsuo, Keitaro
Ito, Hidemi
Iwata, Hiroji
Tajima, Kazuo
Kang, Daehee
Choi, Ji-Yeob
Park, Sue K.
Yoo, Keun-Young
Maishman, Tom
Tapper, William J.
Dunning, Alison
Shah, Mitul
Luben, Robert
Brown, Judith
Khor, Chiea Chuen
Eccles, Diana M.
Nevanlinna, Heli
Easton, Douglas
Humphreys, Keith
Liu, Jianjun
Hall, Per
Czene, Kamila
Title 2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy
Journal name Nature Communications   Check publisher's open access policy
ISSN 2041-1723
Publication date 2014-06-17
Sub-type Article (original research)
DOI 10.1038/ncomms5051
Open Access Status DOI
Volume 5
Start page 1
End page 9
Total pages 9
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2015
Language eng
Abstract Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204-A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10 â ̂'9). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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Created: Thu, 26 Mar 2015, 09:55:05 EST by Matthew Lamb on behalf of School of Medicine