FGF receptor genes and breast cancer susceptibility: Results from the Breast Cancer Association Consortium

Agarwal, D., Pineda, S., Michailidou, K., Herranz, J., Pita, G., Moreno, L. T., Alonso, M. R., Dennis, J., Wang, Q., Bolla, M. K., Meyer, K. B., Menendez-Rodriguez, P., Hardisson, D., Mendiola, M., Gonzalez-Neira, A., Lindblom, A., Margolin, S., Swerdlow, A., Ashworth, A., Orr, N., Jones, M., Matsuo, K., Ito, H., Iwata, H., Kondo, N., Hartman, M., Hui, M., Lim, W. Y., Iau, P. T-C, Sawyer, E., Tomlinson, I., Kerin, M., Miller, N., Kang, D., Choi, J-Y, Park, S. K., Noh, D-Y, Hopper, J. L., Schmidt, D. F., Makalic, E., Southey, M. C., Teo, S. H., Yip, C. H., Sivanandan, K., Tay, W-T, Brauch, H., Bruening, T., Hamann, U., Dunning, A. M., Shah, M., Andrulis, I. L., Knight, J. A., Glendon, G., Tchatchou, S., Schmidt, M. K., Broeks, A., Rosenberg, E. H., van't Veer, L. J., Fasching, P. A., Renner, S. P., Ekici, A. B., Beckmann, M. W., Shen, C-Y, Hsiung, C-N, Yu, J-C, Hou, M-F, Blot, W., Cai, Q., Wu, A. H., Tseng, C-C, Van Den Berg, D., Stram, D. O., Cox, A., Brock, I. W., Reed, M. W. R., Muir, K., Lophatananon, A., Stewart-Brown, S., Siriwanarangsan, P., Zheng, W., Deming-Halverson, S., Shrubsole, M. J., Long, J., Shu, X-O, Lu, W., Gao, Y-T, Zhang, B., Radice, P., Peterlongo, P., Manoukian, S., Mariette, F., Sangrajrang, S., Mckay, J., Couch, F. J., Toland, A. E., Yannoukakos, D., Fletcher, O., Johnson, N., dos Santos Silva, I., Peto, J., Marme, F., Burwinkel, B., Guenel, P., Truong, T., Sanchez, M., Mulot, C., Bojesen, S. E., Nordestgaard, B. G., Flyer, H., Brenner, H., Dieffenbach, A. K., Arndt, V., Stegmaier, C., Mannermaa, A., Kataja, V., Kosma, V-M, Hartikainen, J. M., Lambrechts, D., Yesilyurt, B. T., Floris, G., Leunen, K., Chang-Claude, J., Rudolph, A., Seibold, P., Flesch-Janys, D., Wang, X., Olson, J. E., Vachon, C., Purrington, K., Giles, G. G., Severi, G., Baglietto, L., Haiman, C. A., Henderson, B. E., Schumacher, F., Le Marchand, L., Simard, J., Dumont, M., Goldberg, M. S., Labreche, F., Winqvist, R., Pylkaes, K., Jukkola-Vuorinen, A., Grip, M., Devilee, P., Tollenaar, R. A. E. M., Seynaeve, C., Garcia-Closas, M., Chanock, S. J., Lissowska, J., Figueroa, J. D., Czene, K., Eriksson, M., Humphreys, K., Darabi, H., Hooning, M. J., Kriege, M., Collee, J. M., Tilanus-Linthorst, M., Li, J., Jakubowska, A., Lubinski, J., Jaworska-Bieniek, K., Durda, K., Nevanlinna, H., Muranen, T. A., Aittomaeki, K., Blomqvist, C., Bogdanova, N., Doerk, T., Hall, P., Chenevix-Trench, G., Easton, D. F., Pharoah, P. D. P., Arias-Perez, J. I., Zamora, P., Benitez, J. and Milne, R. L. (2014) FGF receptor genes and breast cancer susceptibility: Results from the Breast Cancer Association Consortium. British Journal of Cancer, 110 4: 1088-1100. doi:10.1038/bjc.2013.769

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Author Agarwal, D.
Pineda, S.
Michailidou, K.
Herranz, J.
Pita, G.
Moreno, L. T.
Alonso, M. R.
Dennis, J.
Wang, Q.
Bolla, M. K.
Meyer, K. B.
Menendez-Rodriguez, P.
Hardisson, D.
Mendiola, M.
Gonzalez-Neira, A.
Lindblom, A.
Margolin, S.
Swerdlow, A.
Ashworth, A.
Orr, N.
Jones, M.
Matsuo, K.
Ito, H.
Iwata, H.
Kondo, N.
Hartman, M.
Hui, M.
Lim, W. Y.
Iau, P. T-C
Sawyer, E.
Tomlinson, I.
Kerin, M.
Miller, N.
Kang, D.
Choi, J-Y
Park, S. K.
Noh, D-Y
Hopper, J. L.
Schmidt, D. F.
Makalic, E.
Southey, M. C.
Teo, S. H.
Yip, C. H.
Sivanandan, K.
Tay, W-T
Brauch, H.
Bruening, T.
Hamann, U.
Dunning, A. M.
Shah, M.
Andrulis, I. L.
Knight, J. A.
Glendon, G.
Tchatchou, S.
Schmidt, M. K.
Broeks, A.
Rosenberg, E. H.
van't Veer, L. J.
Fasching, P. A.
Renner, S. P.
Ekici, A. B.
Beckmann, M. W.
Shen, C-Y
Hsiung, C-N
Yu, J-C
Hou, M-F
Blot, W.
Cai, Q.
Wu, A. H.
Tseng, C-C
Van Den Berg, D.
Stram, D. O.
Cox, A.
Brock, I. W.
Reed, M. W. R.
Muir, K.
Lophatananon, A.
Stewart-Brown, S.
Siriwanarangsan, P.
Zheng, W.
Deming-Halverson, S.
Shrubsole, M. J.
Long, J.
Shu, X-O
Lu, W.
Gao, Y-T
Zhang, B.
Radice, P.
Peterlongo, P.
Manoukian, S.
Mariette, F.
Sangrajrang, S.
Mckay, J.
Couch, F. J.
Toland, A. E.
Yannoukakos, D.
Fletcher, O.
Johnson, N.
dos Santos Silva, I.
Peto, J.
Marme, F.
Burwinkel, B.
Guenel, P.
Truong, T.
Sanchez, M.
Mulot, C.
Bojesen, S. E.
Nordestgaard, B. G.
Flyer, H.
Brenner, H.
Dieffenbach, A. K.
Arndt, V.
Stegmaier, C.
Mannermaa, A.
Kataja, V.
Kosma, V-M
Hartikainen, J. M.
Lambrechts, D.
Yesilyurt, B. T.
Floris, G.
Leunen, K.
Chang-Claude, J.
Rudolph, A.
Seibold, P.
Flesch-Janys, D.
Wang, X.
Olson, J. E.
Vachon, C.
Purrington, K.
Giles, G. G.
Severi, G.
Baglietto, L.
Haiman, C. A.
Henderson, B. E.
Schumacher, F.
Le Marchand, L.
Simard, J.
Dumont, M.
Goldberg, M. S.
Labreche, F.
Winqvist, R.
Pylkaes, K.
Jukkola-Vuorinen, A.
Grip, M.
Devilee, P.
Tollenaar, R. A. E. M.
Seynaeve, C.
Garcia-Closas, M.
Chanock, S. J.
Lissowska, J.
Figueroa, J. D.
Czene, K.
Eriksson, M.
Humphreys, K.
Darabi, H.
Hooning, M. J.
Kriege, M.
Collee, J. M.
Tilanus-Linthorst, M.
Li, J.
Jakubowska, A.
Lubinski, J.
Jaworska-Bieniek, K.
Durda, K.
Nevanlinna, H.
Muranen, T. A.
Aittomaeki, K.
Blomqvist, C.
Bogdanova, N.
Doerk, T.
Hall, P.
Chenevix-Trench, G.
Easton, D. F.
Pharoah, P. D. P.
Arias-Perez, J. I.
Zamora, P.
Benitez, J.
Milne, R. L.
Title FGF receptor genes and breast cancer susceptibility: Results from the Breast Cancer Association Consortium
Journal name British Journal of Cancer   Check publisher's open access policy
ISSN 0007-0920
1532-1827
Publication date 2014-02-18
Sub-type Article (original research)
DOI 10.1038/bjc.2013.769
Open Access Status DOI
Volume 110
Issue 4
Start page 1088
End page 1100
Total pages 13
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2015
Language eng
Abstract Background:Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium.Methods:Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.Results:Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02-1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2.Conclusion:Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
 
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Created: Thu, 26 Mar 2015, 09:39:02 EST by Matthew Lamb on behalf of School of Medicine