The mediating effect of body mass index on the relationship between cigarette smoking and atopic sensitization in Chinese adults

Luo, Xiao, Wang, Yupeng, Wang, Zhiqiang, Cai, Fuwen, Xie, Biao, Qu, Siyang and Liu, Meina (2015) The mediating effect of body mass index on the relationship between cigarette smoking and atopic sensitization in Chinese adults. International Journal of Environmental Research and Public Health, 12 3: 3381-3394. doi:10.3390/ijerph120303381

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Author Luo, Xiao
Wang, Yupeng
Wang, Zhiqiang
Cai, Fuwen
Xie, Biao
Qu, Siyang
Liu, Meina
Title The mediating effect of body mass index on the relationship between cigarette smoking and atopic sensitization in Chinese adults
Journal name International Journal of Environmental Research and Public Health   Check publisher's open access policy
ISSN 1660-4601
1661-7827
Publication date 2015-03-23
Sub-type Article (original research)
DOI 10.3390/ijerph120303381
Open Access Status DOI
Volume 12
Issue 3
Start page 3381
End page 3394
Total pages 14
Place of publication Basel, Switzerland
Publisher MDPI AG
Collection year 2016
Language eng
Formatted abstract
Background: It is unclear whether the relationship between cigarette smoking and atopy is mediated by body fat mass, such as the Body Mass Index (BMI). We assessed the mediating role of BMI on the relationship between smoking and atopy in Chinese adults. Methods: A hospital-based case-control study of 786 atopic cases and 2771 controls was conducted in adults aged 18 years or older from March 2010 to September 2014 in Harbin, China. Mediation models were used to estimate the indirect effects of smoking on atopic sensitization through BMI. Results: Compared to non-smokers, light smokers and moderate smokers had a lower risk of inhalant allergen sensitization. The indirect effect of smoking and sensitization to aeroallergens were only observed in light smokers (point estimate, −0.026; 95% CI, −0.062 to −0.004). The mediating roles of BMI on the relationships between smoking and other types of allergic sensitization were not statistically significant. Conclusion: BMI appeared to partially mediate the effect of light smoking on sensitization to aeroallergens. However, considering the other harmful health effects of cigarette smoking, the effective method to lower the incidence of atopy would be to decrease body fat mass by physical exercise and employing other more healthy ways of living rather than smoking.
Keyword Cigarette smoking
Body mass index
Mediator
Atopy
Adults
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2016 Collection
 
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Created: Tue, 24 Mar 2015, 11:40:35 EST by Zhiqiang Wang on behalf of Medicine - Royal Brisbane and Women's Hospital