Epstein-Barr virus-specific adoptive immunotherapy for progressive multiple sclerosis

Pender, Michael P., Csurhes, Peter A., Smith, Corey, Beagley, Leone, Hooper, Kaye D., Raj, Meenakshi, Coulthard, Alan, Burrows, Scott R. and Khanna, Rajiv (2014) Epstein-Barr virus-specific adoptive immunotherapy for progressive multiple sclerosis. Multiple Sclerosis Journal, 20 11: 1541-1544. doi:10.1177/1352458514521888

Author Pender, Michael P.
Csurhes, Peter A.
Smith, Corey
Beagley, Leone
Hooper, Kaye D.
Raj, Meenakshi
Coulthard, Alan
Burrows, Scott R.
Khanna, Rajiv
Title Epstein-Barr virus-specific adoptive immunotherapy for progressive multiple sclerosis
Journal name Multiple Sclerosis Journal   Check publisher's open access policy
ISSN 1352-4585
Publication date 2014-02-03
Year available 2014
Sub-type Article (original research)
DOI 10.1177/1352458514521888
Open Access Status
Volume 20
Issue 11
Start page 1541
End page 1544
Total pages 4
Place of publication London, United Kingdom
Publisher Sage Publications
Collection year 2015
Language eng
Formatted abstract
Defective control of Epstein–Barr virus (EBV) infection by cytotoxic CD8+ T cells might predispose to multiple sclerosis (MS) by allowing EBV-infected autoreactive B cells to accumulate in the central nervous system. We have treated a patient with secondary progressive MS with in vitro-expanded autologous EBV-specific CD8+ T cells directed against viral latent proteins. This adoptive immunotherapy had no adverse effects and the patient showed clinical improvement with reduced disease activity on magnetic resonance imaging and decreased intrathecal immunoglobulin production. This is the first report of the use of EBV-specific adoptive immunotherapy to treat MS or any other autoimmune disease.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2015 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
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Created: Tue, 24 Mar 2015, 11:19:11 EST by Mr Peter Csurhes on behalf of Medicine - Royal Brisbane and Women's Hospital