Circulating tumour cells in metastatic head and neck cancers

Kulasinghe, Arutha, Perry, Chris, Jovanovic, Lidija, Nelson, Colleen and Chamindie Punyadeera, (2015) Circulating tumour cells in metastatic head and neck cancers. International Journal of Cancer, 136 11: 2515-2523. doi:10.1002/ijc.29108

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Author Kulasinghe, Arutha
Perry, Chris
Jovanovic, Lidija
Nelson, Colleen
Chamindie Punyadeera,
Title Circulating tumour cells in metastatic head and neck cancers
Journal name International Journal of Cancer   Check publisher's open access policy
ISSN 0020-7136
Publication date 2015-06-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/ijc.29108
Open Access Status
Volume 136
Issue 11
Start page 2515
End page 2523
Total pages 9
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2015
Language eng
Formatted abstract
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer with 650,000 new cases p/a worldwide. HNSCC causes high morbidity with a 5-year survival rate of less than 60%, which has not improved due to the lack of early detection (Bozec et al. Eur Arch Otorhinolaryngol. 2013;270: 2745–9 DOI:10.1007/s00405-013-2399-y). Metastatic disease remains one of the leading causes of death in HNSCC patients. This review article provides a comprehensive overview of literature over the past 5 years on the detection of circulating tumour cells (CTCs) in HNSCC; CTC biology and future perspectives. CTCs are a hallmark of invasive cancer cells and key to metastasis. CTCs can be used as surrogate markers of overall survival and progression-free survival. CTCs are currently used as prognostic factors for breast, prostate and colorectal cancers using the CellSearch® system. CTCs have been detected in HNSCC, however, these numbers depend on the technique applied, time of blood collection and the clinical stage of the patient. The impact of CTCs in HNSCC is not well understood, and thus, not in routine clinical practice. Validated detection technologies that are able to capture CTCs undergoing epithelial–mesenchymal transition are needed. This will aid in the capture of heterogeneous CTCs, which can be compiled as new targets for the current food and drug administration-cleared CellSearch® system. Recent studies on CTCs in HNSCC with the CellSearch® have shown variable data. Therefore, there is an immediate need for large clinical trials encompassing a suite of biomarkers capturing CTCs in HNSCC, before CTCs can be used as prognostic markers in HNSCC patient management.
Keyword Circulating tumour cells
Head and neck squamous cell carcinoma
Head and neck cancer
Epithelial–mesenchymal transition
Circulating tumour cells
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 11 AUG 2014

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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Created: Thu, 19 Mar 2015, 11:53:13 EST by Kylie Hengst on behalf of UQ Diamantina Institute