Long-term clozapine treatment identifies significant improvements in clinical and functioning scales

Chatterton, R., McGrath, J., Sanderson, L., van Leent, S. and Chant, D. (1999). Long-term clozapine treatment identifies significant improvements in clinical and functioning scales. In: Schizophrenia Research: Abstracts of the VIIth International Congress on Schizophrenia Research. VIIth International Congress on Schizophrenia Research, Santa Fe, New Mexico, (274-274). 17-21 April, 1999. doi:10.1016/S0920-9964(99)90039-7


Author Chatterton, R.
McGrath, J.
Sanderson, L.
van Leent, S.
Chant, D.
Title of paper Long-term clozapine treatment identifies significant improvements in clinical and functioning scales
Conference name VIIth International Congress on Schizophrenia Research
Conference location Santa Fe, New Mexico
Conference dates 17-21 April, 1999
Proceedings title Schizophrenia Research: Abstracts of the VIIth International Congress on Schizophrenia Research   Check publisher's open access policy
Journal name Schizophrenia Research   Check publisher's open access policy
Place of Publication Amsterdam
Publisher Elsevier
Publication Year 1999
DOI 10.1016/S0920-9964(99)90039-7
ISSN 0920-9964
Volume 36
Issue 1-3
Start page 274
End page 274
Total pages 1
Language eng
Abstract/Summary The majority of clinical drug trials only cover a small number of variables over a short period of time on a small group of people. The objective of this study was to track a large group of people over a long period of time, using a diverse range of variables with a naturalistic design to assess the ‘real world’ use of clozapine. Fifty-three people with treatment-resistant schizophrenia were recruited into a 2-year study which assessed the subjects using the following scales: Positive and Negative Syndrome Scale (PANSS), Clinical Global Impression Scale (CGI), Life Skills Profile (LSP), and Role Functioning Scale (RFS). Discharge, leave, and ward movement rates were also monitored. All subjects were inpatients at a tertiary psychiatric facility. Thirty-three percent of the group was discharged. Seventythree percent moved to less cost-intensive wards, and the leave rate increased by 105”/0. Sixty-seven percent of the study group were identified as responders by the 24-month time point. Twenty-four percent of the group had their CGI scores reduced to 2 or better 0, =O.OOOl). Significant improvements were identified in the RFS (p = 0.02) and LSP (p = 0.0001). Long-term clozapine treatment has identified a significant group of responders on a variety of measures.
Subjects 110319 Psychiatry (incl. Psychotherapy)
111714 Mental Health
Keyword Psychiatry
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Therapeutics: Treatment trials

Document type: Conference Paper
Collection: School of Medicine Publications
 
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Created: Mon, 13 Aug 2007, 20:55:17 EST