Copy number variants and therapeutic response to antidepressant medication in major depressive disorder

Tansey, K. E., Rucker, J. J. H., Kavanagh, D. H., Guipponi, M., Perroud, N., Bondolfi, G., Domenici, E., Evans, D. M., Hausers, J., Henigsberg, N., Jerman, B., Maier, W., Mors, O., O'Donovan, M., Peters, T. J., Placentino, A., Rietschel, M., Souery, D., Aitchison, K. J., Craig, I., Farmer, A., Wendland, J. R., Malafosse, A., Lewis, G., Kapur, S., McGuffin, P. and Uher, R. (2014) Copy number variants and therapeutic response to antidepressant medication in major depressive disorder. Pharmacogenomics Journal, 14 4: 395-399. doi:10.1038/tpj.2013.51

Author Tansey, K. E.
Rucker, J. J. H.
Kavanagh, D. H.
Guipponi, M.
Perroud, N.
Bondolfi, G.
Domenici, E.
Evans, D. M.
Hausers, J.
Henigsberg, N.
Jerman, B.
Maier, W.
Mors, O.
O'Donovan, M.
Peters, T. J.
Placentino, A.
Rietschel, M.
Souery, D.
Aitchison, K. J.
Craig, I.
Farmer, A.
Wendland, J. R.
Malafosse, A.
Lewis, G.
Kapur, S.
McGuffin, P.
Uher, R.
Title Copy number variants and therapeutic response to antidepressant medication in major depressive disorder
Journal name Pharmacogenomics Journal   Check publisher's open access policy
ISSN 1473-1150
Publication date 2014-08
Year available 2014
Sub-type Article (original research)
DOI 10.1038/tpj.2013.51
Open Access Status
Volume 14
Issue 4
Start page 395
End page 399
Total pages 5
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2015
Language eng
Abstract It would be beneficial to find genetic predictors of antidepressant response to help personalise treatment of major depressive disorder (MDD). Rare copy number variants (CNVs) have been implicated in several psychiatric disorders, including MDD, but their role in antidepressant response has yet to be investigated. CNV data were available for 1565 individuals with MDD from the NEWMEDS (Novel Methods leading to New Medications in Depression and Schizophrenia) consortium with prospective data on treatment outcome with either a serotonergic or noradrenergic antidepressant. No association was seen between the presence of CNV (rare or common), the overall number of CNVs or genomic CNV 'burden' and antidepressant response. Specific CNVs were nominally associated with antidepressant response, including 15q13.3 duplications and exonic NRXN1 deletions. These were associated with poor response to antidepressants. Overall burden of CNVs is unlikely to contribute to personalising antidepressant treatment. Specific CNVs associated with antidepressant treatment require replication and further study to confirm their role in the therapeutic action of antidepressant.
Keyword Antidepressant
Copy number variants
Major depressive disorder
Treatment response
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 18 Mar 2015, 20:38:16 EST by David Evans on behalf of UQ Diamantina Institute