Harmonization of neuroticism and extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of item response theory

van den Berg, Stephanie M., de Moor, Marleen H. M., McGue, Matt, Pettersson, Erik, Terracciano, Antonio, Verweij, Karin J. H., Amin, Najaf, Derringer, Jaime, Esko, Tonu, van Grootheest, Gerard, Hansell, Narelle K., Huffman, Jennifer, Konte, Bettina, Lahti, Jari, Luciano, Michelle, Matteson, Lindsay K., Viktorin, Alexander, Wouda, Jasper, Agrawal, Arpana, Allik, Jueri, Bierut, Laura, Broms, Ulla, Campbell, Harry, Smith, George Davey, Eriksson, Johan G., Ferrucci, Luigi, Franke, Barbera, Fox, Jean-Paul, de Geus, Eco J. C., Giegling, Ina, Gow, Alan J., Grucza, Richard, Hartmann, Annette M., Heath, Andrew C., Heikkilae, Kauko, Iacono, William G., Janzing, Joost, Jokela, Markus, Kiemeney, Lambertus, Lehtimaki, Terho, Madden, Pamela A. F., Magnusson, Patrik K. E., Northstone, Kate, Nutile, Teresa, Ouwens, Klaasjan G., Palotie, Aarno, Pattie, Alison, Pesonen, Anu-Katriina, Polasek, Ozren, Pulkkinen, Lea, Pulkki-Raback, Laura, Raitakari, Olli T., Realo, Anu, Rose, Richard J., Ruggiero, Daniela, Seppala, Ilkka, Slutske, Wendy S., Smyth, David C., Sorice, Rossella, Starr, John M., Sutin, Angelina R., Tanaka, Toshiko, Verhagen, Josine, Vermeulen, Sita, Vuoksimaa, Eero, Widen, Elisabeth, Willemsen, Gonneke, Wright, Margaret J., Zgaga, Lina, Rujescu, Dan, Metspalu, Andres, Wilson, James F., Ciullo, Marina, Hayward, Caroline, Rudan, Igor, Deary, Ian J., Raikkonen, Katri, Vasquez, Alejandro Arias, Costa, Paul T., Keltikangas-Jarvinen, Liisa, van Duijn, Cornelia M., Penninx, Brenda W. J. H., Krueger, Robert F., Evans, David M., Kaprio, Jaakko, Pedersen, Nancy L., Martin, Nicholas G. and Boomsma, Dorret I. (2014) Harmonization of neuroticism and extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of item response theory. Behavior Genetics, 44 4: 295-313. doi:10.1007/s10519-014-9654-x


Author van den Berg, Stephanie M.
de Moor, Marleen H. M.
McGue, Matt
Pettersson, Erik
Terracciano, Antonio
Verweij, Karin J. H.
Amin, Najaf
Derringer, Jaime
Esko, Tonu
van Grootheest, Gerard
Hansell, Narelle K.
Huffman, Jennifer
Konte, Bettina
Lahti, Jari
Luciano, Michelle
Matteson, Lindsay K.
Viktorin, Alexander
Wouda, Jasper
Agrawal, Arpana
Allik, Jueri
Bierut, Laura
Broms, Ulla
Campbell, Harry
Smith, George Davey
Eriksson, Johan G.
Ferrucci, Luigi
Franke, Barbera
Fox, Jean-Paul
de Geus, Eco J. C.
Giegling, Ina
Gow, Alan J.
Grucza, Richard
Hartmann, Annette M.
Heath, Andrew C.
Heikkilae, Kauko
Iacono, William G.
Janzing, Joost
Jokela, Markus
Kiemeney, Lambertus
Lehtimaki, Terho
Madden, Pamela A. F.
Magnusson, Patrik K. E.
Northstone, Kate
Nutile, Teresa
Ouwens, Klaasjan G.
Palotie, Aarno
Pattie, Alison
Pesonen, Anu-Katriina
Polasek, Ozren
Pulkkinen, Lea
Pulkki-Raback, Laura
Raitakari, Olli T.
Realo, Anu
Rose, Richard J.
Ruggiero, Daniela
Seppala, Ilkka
Slutske, Wendy S.
Smyth, David C.
Sorice, Rossella
Starr, John M.
Sutin, Angelina R.
Tanaka, Toshiko
Verhagen, Josine
Vermeulen, Sita
Vuoksimaa, Eero
Widen, Elisabeth
Willemsen, Gonneke
Wright, Margaret J.
Zgaga, Lina
Rujescu, Dan
Metspalu, Andres
Wilson, James F.
Ciullo, Marina
Hayward, Caroline
Rudan, Igor
Deary, Ian J.
Raikkonen, Katri
Vasquez, Alejandro Arias
Costa, Paul T.
Keltikangas-Jarvinen, Liisa
van Duijn, Cornelia M.
Penninx, Brenda W. J. H.
Krueger, Robert F.
Evans, David M.
Kaprio, Jaakko
Pedersen, Nancy L.
Martin, Nicholas G.
Boomsma, Dorret I.
Title Harmonization of neuroticism and extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of item response theory
Journal name Behavior Genetics   Check publisher's open access policy
ISSN 1573-3297
0001-8244
Publication date 2014-07
Year available 2014
Sub-type Article (original research)
DOI 10.1007/s10519-014-9654-x
Open Access Status
Volume 44
Issue 4
Start page 295
End page 313
Total pages 19
Place of publication New York, NY United States
Publisher Springer New York
Collection year 2015
Language eng
Abstract Mega- or meta-analytic studies (e.g. genome-wide association studies) are increasingly used in behavior genetics. An issue in such studies is that phenotypes are often measured by different instruments across study cohorts, requiring harmonization of measures so that more powerful fixed effect meta-analyses can be employed. Within the Genetics of Personality Consortium, we demonstrate for two clinically relevant personality traits, Neuroticism and Extraversion, how Item-Response Theory (IRT) can be applied to map item data from different inventories to the same underlying constructs. Personality item data were analyzed in >160,000 individuals from 23 cohorts across Europe, USA and Australia in which Neuroticism and Extraversion were assessed by nine different personality inventories. Results showed that harmonization was very successful for most personality inventories and moderately successful for some. Neuroticism and Extraversion inventories were largely measurement invariant across cohorts, in particular when comparing cohorts from countries where the same language is spoken. The IRT-based scores for Neuroticism and Extraversion were heritable (48 and 49 %, respectively, based on a meta-analysis of six twin cohorts, total N = 29,496 and 29,501 twin pairs, respectively) with a significant part of the heritability due to non-additive genetic factors. For Extraversion, these genetic factors qualitatively differ across sexes. We showed that our IRT method can lead to a large increase in sample size and therefore statistical power. The IRT approach may be applied to any mega- or meta-analytic study in which item-based behavioral measures need to be harmonized.
Keyword Personality
Item-Response Theory
Measurement
Genome-wide association studies
Consortium
Meta-analysis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
UQ Diamantina Institute Publications
 
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Created: Wed, 18 Mar 2015, 20:25:31 EST by David Evans on behalf of UQ Diamantina Institute