Lung cancer vaccines: current status and future prospects

Ramlogan-Steel, Charmaine A., Steel, Jason C. and Morris, John C. (2014) Lung cancer vaccines: current status and future prospects. Translational Lung Cancer Research, 3 1: 46-52. doi:10.3978/j.issn.2218-6751.2013.12.01

Author Ramlogan-Steel, Charmaine A.
Steel, Jason C.
Morris, John C.
Title Lung cancer vaccines: current status and future prospects
Journal name Translational Lung Cancer Research   Check publisher's open access policy
ISSN 2218-6751
Publication date 2014-02
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3978/j.issn.2218-6751.2013.12.01
Open Access Status
Volume 3
Issue 1
Start page 46
End page 52
Total pages 7
Editor Yasuhiko Nishioka
Place of publication Hong Kong, Hong Kong
Publisher Pioneer Bioscience Publishing Company
Collection year 2015
Language eng
Formatted abstract
Designing a cancer treatment that very specifically targets and kills tumor cells with little to no side effects is the “holy grail” of oncology. Cancer vaccines have this potential. Vaccines utilize the immune system to specifically target and eliminate tumor cells. Historically, vaccination approaches against lung cancer have been disappointing. However, over the past decade, a greater understanding of the immune system and of the antigens expressed by tumors, coupled with advances in immunoadjuvants and improved delivery systems, has led to advances in the use of immunotherapy including vaccines to target lung cancer. Proof of principle phase I/II clinical trials targeting the MAGE-A3 and MUC1 tumor antigens, as well as cell-based vaccines such as belagenpumatucel-L have suggested improved survival, leading to larger scale phase III clinical trials. This review will discuss cancer vaccines in relation to lung cancer and present clinical data supporting their use.
Keyword Lung cancer
Cancer vaccines
Clinical trials
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
School of Medicine Publications
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Citation counts: Scopus Citation Count Cited 6 times in Scopus Article | Citations
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Created: Tue, 17 Mar 2015, 16:32:27 EST by Jason Steel on behalf of Medicine - Greenslopes Private Hospital