Cell contact dependent extended release of adenovirus by microparticles in vitro

Cavanagh, Heather M. A., Dingwall, Daniel, Steel, Jason, Benson, James and Burton, Mark (2001) Cell contact dependent extended release of adenovirus by microparticles in vitro. Journal of Virological Methods, 95 1-2: 57-64. doi:10.1016/S0166-0934(01)00291-9


Author Cavanagh, Heather M. A.
Dingwall, Daniel
Steel, Jason
Benson, James
Burton, Mark
Title Cell contact dependent extended release of adenovirus by microparticles in vitro
Journal name Journal of Virological Methods   Check publisher's open access policy
ISSN 0166-0934
1879-0984
Publication date 2001-06
Sub-type Article (original research)
DOI 10.1016/S0166-0934(01)00291-9
Open Access Status Not yet assessed
Volume 95
Issue 1-2
Start page 57
End page 64
Total pages 8
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Abstract Adenoviral vectors remain one of the most promising methods of gene delivery but are plagued by several inherent problems including immune inactivation and transient expression. This paper reports a novel microparticle-based delivery system for adenovirus that allows high uptake of virus, stable complex formation and extended release. In addition, this microparticle/adenovirus complex has been demonstrated to only release virus upon cell contact. The significant clinical implications of this delivery system are discussed.
Keyword Adenovirus
Gene transfer
Microparticle complexing
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Tue, 17 Mar 2015, 16:11:50 EST by Jason Steel on behalf of Learning and Research Services (UQ Library)