Interleukin-15 biology and its therapeutic implications in cancer

Steel, Jason C., Waldmann, Thomas A. and Morris, John C. (2012) Interleukin-15 biology and its therapeutic implications in cancer. Trends in Pharmacological Sciences, 33 1: 35-41. doi:10.1016/j.tips.2011.09.004


Author Steel, Jason C.
Waldmann, Thomas A.
Morris, John C.
Title Interleukin-15 biology and its therapeutic implications in cancer
Journal name Trends in Pharmacological Sciences   Check publisher's open access policy
ISSN 0165-6147
1873-3735
Publication date 2012
Year available 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.tips.2011.09.004
Open Access Status
Volume 33
Issue 1
Start page 35
End page 41
Total pages 7
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier
Language eng
Abstract Cancer immunotherapy is designed to stimulate the immune system to reject and destroy tumors. Recently, interleukin-15 (IL-15), a member of the four α-helix bundle family of cytokines, has emerged as a candidate immunomodulator for the treatment of cancer. IL-15 acts through its specific receptor, IL-15Rα, which is expressed on antigen-presenting dendritic cells, monocytes and macrophages. IL-15 exhibits broad activity and induces the differentiation and proliferation of T, B and natural killer (NK) cells. It also enhances the cytolytic activity of CD8 + T cells and induces long-lasting antigen-experienced CD8 +CD44 hi memory T cells. IL-15 stimulates differentiation and immunoglobulin synthesis by B cells and induces maturation of dendritic cells. It does not stimulate immunosuppressive T regulatory cells (Tregs). Thus, boosting IL-15 activity could enhance innate and specific immunity and fight tumors. Here we review aspects of IL-15 biology that make it a promising agent for anticancer therapy. We also discuss preclinical models in which IL-15 has demonstrated antitumor activity and highlight ongoing clinical trials of IL-15 in patients with cancer and HIV infection.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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Created: Tue, 17 Mar 2015, 16:04:45 EST by Jason Steel on behalf of Medicine - Greenslopes Private Hospital