Prefrontal and Auditory Input to Intercalated Neurons of the Amygdala

Strobel, Cornelia, Marek, Roger, Gooch, Helen, Sullivan, Robert K. P. and Sah, Pankaj (2015) Prefrontal and Auditory Input to Intercalated Neurons of the Amygdala. Cell Reports, 10 9: 1435-1442. doi:10.1016/j.celrep.2015.02.008

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Author Strobel, Cornelia
Marek, Roger
Gooch, Helen
Sullivan, Robert K. P.
Sah, Pankaj
Title Prefrontal and Auditory Input to Intercalated Neurons of the Amygdala
Journal name Cell Reports   Check publisher's open access policy
ISSN 2211-1247
Publication date 2015-03-05
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.celrep.2015.02.008
Open Access Status DOI
Volume 10
Issue 9
Start page 1435
End page 1442
Total pages 8
Place of publication New York, NY United States
Publisher Elsevier
Collection year 2016
Language eng
Formatted abstract
The basolateral amygdala (BLA) and prefrontal cortex (PFC) are partners in fear learning and extinction. Intercalated (ITC) cells are inhibitory neurons that surround the BLA. Lateral ITC (lITC) neurons provide feed-forward inhibition to BLA principal neurons, whereas medial ITC (mITC) neurons form an inhibitory interface between the BLA and central amygdala (CeA). Notably, infralimbic prefrontal (IL) input to mITC neurons is thought to play a key role in fear extinction. Here, using targeted optogenetic stimulation, we show that lITC neurons receive auditory input from cortical and thalamic regions. IL inputs innervate principal neurons in the BLA but not mITC neurons. These results suggest that (1) these neurons may play a more central role in fear learning as both lITCs and mITCs receive auditory input and that (2) mITC neurons cannot be driven directly by the IL, and their role in fear extinction is likely mediated via the BLA.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 16 times in Scopus Article | Citations
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