Nanotechnology in the management of cervical cancer

Chen, Jiezhong, Gu, Wenyi, Yang, Lei, Chen, Chen, Shao, Renfu, Xu, Kewei and Xu, Zhi Ping (2015) Nanotechnology in the management of cervical cancer. Reviews in Medical Virology, 25 S1: 72-83. doi:10.1002/rmv.1825

Author Chen, Jiezhong
Gu, Wenyi
Yang, Lei
Chen, Chen
Shao, Renfu
Xu, Kewei
Xu, Zhi Ping
Title Nanotechnology in the management of cervical cancer
Journal name Reviews in Medical Virology   Check publisher's open access policy
ISSN 1099-1654
Publication date 2015-03-01
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/rmv.1825
Open Access Status
Volume 25
Issue S1
Start page 72
End page 83
Total pages 12
Place of publication Chichester, West Sussex United Kingdom
Publisher John Wiley & Sons
Collection year 2015
Language eng
Abstract Cervical cancer is a major disease with high mortality. All cervical cancers are caused by infection with human papillomaviruses (HPV). Although preventive vaccines for cervical cancer are successful, treatment of cervical cancer is far less satisfactory because of multidrug resistance and side effects. In this review, we summarize the recent application of nanotechnology to the diagnosis and treatment of cervical cancer as well as the development of HPV vaccines. Early detection of cervical cancer enables tumours to be efficiently removed by surgical procedures, leading to increased survival rate. The current method of detecting cervical cancer by Pap smear can only achieve 50% sensitivity, whereas nanotechnology has been used to detect HPVs with greatly improved sensitivity. In cervical cancer treatment, nanotechnology has been used for the delivery of anticancer drugs to increase treatment efficacy and decrease side effects. Nanodelivery of HPV preventive and therapeutic vaccines has also been investigated to increase vaccine efficacy. Overall, these developments suggest that nanoparticle-based vaccine may become the most effective way to prevent and treat cervical cancer, assisted or combined with some other nanotechnology-based therapy.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
School of Biomedical Sciences Publications
School of Medicine Publications
Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 4 times in Scopus Article | Citations
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