Analysis of biological networks and biological pathways associated with residual feed intake in beef cattle

Karisa, Brian, Moore, Stephen and Plastow, Graham (2014) Analysis of biological networks and biological pathways associated with residual feed intake in beef cattle. Animal Science Journal, 85 4: 374-387. doi:10.1111/asj.12159


Author Karisa, Brian
Moore, Stephen
Plastow, Graham
Title Analysis of biological networks and biological pathways associated with residual feed intake in beef cattle
Journal name Animal Science Journal   Check publisher's open access policy
ISSN 1344-3941
1740-0929
Publication date 2014-04
Year available 2013
Sub-type Article (original research)
DOI 10.1111/asj.12159
Open Access Status Not yet assessed
Volume 85
Issue 4
Start page 374
End page 387
Total pages 14
Place of publication Richmond, VIC Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2015
Language eng
Abstract In this study, biological networks were reconstructed from genes and metabolites significantly associated with residual feed intake (RFI) in beef cattle. The networks were then used to identify biological pathways associated with RFI. RFI is a measure of feed efficiency, which is independent of body size and growth; therefore selection for RFI is expected to result in cattle that consume less feed without adverse effects on growth rate and mature size. Although several studies have identified genes associated with RFI, the mechanisms of the biological processes are not well understood. In this study, we utilised the results obtained from two association studies, one using 24 genes and one using plasma metabolites to reconstruct biological networks associated with RFI using IPA software (Igenuity Systems). The results pointed to biological processes such as lipid and steroid biosynthesis, protein and carbohydrate metabolism and regulation of gene expression through DNA transcription, protein stability and degradation. The major canonical pathways included signaling of growth hormone, Oncostatin M, insulin-like growth factor and AMP activated protein kinase, and cholesterol biosynthesis. This study provides information on potential biological mechanisms, and genes and metabolites involved in feed efficiency in beef cattle.
Keyword Beef cattle
Biological networks
Genes
Metabolites
Residual feed intake
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Alliance for Agriculture and Food Innovation
 
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Created: Mon, 16 Mar 2015, 14:15:52 EST by Christopher O'Keefe on behalf of Centre for Animal Science