Advancing parental age and autism: multifactorial pathways

Lee, Brian K. and McGrath, John J. (2015) Advancing parental age and autism: multifactorial pathways. Trends In Molecular Medicine, 21 2: 118-125. doi:10.1016/j.molmed.2014.11.005

Author Lee, Brian K.
McGrath, John J.
Title Advancing parental age and autism: multifactorial pathways
Journal name Trends In Molecular Medicine   Check publisher's open access policy
ISSN 1471-499X
Publication date 2015-02
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.molmed.2014.11.005
Open Access Status
Volume 21
Issue 2
Start page 118
End page 125
Total pages 8
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier Trends Journals
Collection year 2015
Language eng
Formatted abstract
• Both advancing paternal age and maternal age increase the risk of autism in the offspring.
• Different mechanisms likely underlie paternal and maternal age effects.

Converging evidence from epidemiological, genetic, and animal studies supports the hypothesis that advancing parental age, both of the father and mother, increases the risk of autism spectrum disorders (ASD) in offspring. Paternal age has received considerable attention, with whole-genome sequencing studies linking older fathers to higher rates of de novo mutations and increased risk of ASD. The current evidence suggests that the increased risk of ASD in the offspring of older mothers may be related to mechanisms different from those operating in older fathers. Causal pathways probably involve the interaction of multiple risk factors. Although the etiology of ASD is still poorly understood, studies of parental age provide clues into the genetic and environmental mechanisms that mediate the risk of ASD.
Keyword Autism
Parental age
de Novo mutations
Animal models
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 3 February 2015

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 5 times in Scopus Article | Citations
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Created: Fri, 13 Mar 2015, 15:21:14 EST by Susan Day on behalf of Queensland Brain Institute