Effectiveness and safety of infliximab in two cases of severe chondrocalcinosis: nine years of follow-up

Bruges-Armas, Jácome, Bettencourt, Bruno F., Couto, Ana R., Lima, Manuela, Rodrigues, Ana M., Vastesaeger, Nathan and Brown, Matthew A. (2014) Effectiveness and safety of infliximab in two cases of severe chondrocalcinosis: nine years of follow-up. Case Reports in Rheumatology, 2014 536856: 1-6. doi:10.1155/2014/536856


Author Bruges-Armas, Jácome
Bettencourt, Bruno F.
Couto, Ana R.
Lima, Manuela
Rodrigues, Ana M.
Vastesaeger, Nathan
Brown, Matthew A.
Title Effectiveness and safety of infliximab in two cases of severe chondrocalcinosis: nine years of follow-up
Journal name Case Reports in Rheumatology   Check publisher's open access policy
ISSN 2090-6889
2090-6897
Publication date 2014-11-11
Sub-type Article (original research)
DOI 10.1155/2014/536856
Open Access Status DOI
Volume 2014
Issue 536856
Start page 1
End page 6
Total pages 6
Place of publication New York, NY, United States
Publisher Hindawi Publishing
Collection year 2015
Language eng
Formatted abstract
Objectives. To investigate the efficacy of infliximab in the treatment of severe calcium pyrophosphate deposition diseases (CPPD).

Methods. Two patients with severe CPPD and diffuse idiopathic skeletal hyperostosis- (DISH-) like phenotype are described. Both patients were resistant to therapy with nonsteroidal anti-inflammatory drugs (NSAIDs). Both patients were treated with infliximab, a TNF-α receptor antagonist, for nine years.

Results. Treatment with infliximab resulted in major clinical and laboratory improvements without relevant side effects.

Conclusions. These results suggest that infliximab may be an effective treatment of severe CPDD.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
UQ Diamantina Institute Publications
 
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Created: Fri, 13 Mar 2015, 13:38:12 EST by Kylie Hengst on behalf of UQ Diamantina Institute