Negative pressure wound therapy on surgical site infections in women undergoing elective caesarean sections: a pilot RCT

Chaboyer, Wendy, Anderson, Vinah, Webster, Joan, Sneddon, Anne, Thalib, Lukman and Gillespie, Brigid M. (2014) Negative pressure wound therapy on surgical site infections in women undergoing elective caesarean sections: a pilot RCT. Healthcare, 2 4: 417-428. doi:10.3390/healthcare2040417

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Author Chaboyer, Wendy
Anderson, Vinah
Webster, Joan
Sneddon, Anne
Thalib, Lukman
Gillespie, Brigid M.
Title Negative pressure wound therapy on surgical site infections in women undergoing elective caesarean sections: a pilot RCT
Journal name Healthcare   Check publisher's open access policy
ISSN 2227-9032
Publication date 2014-09-30
Year available 2014
Sub-type Article (original research)
DOI 10.3390/healthcare2040417
Open Access Status DOI
Volume 2
Issue 4
Start page 417
End page 428
Total pages 12
Place of publication Basel, Switzerland
Publisher MDPI AG
Collection year 2015
Language eng
Abstract Obese women undergoing caesarean section (CS) are at increased risk of surgical site infection (SSI). Negative Pressure Wound Therapy (NPWT) is growing in use as a prophylactic approach to prevent wound complications such as SSI, yet there is little evidence of its benefits. This pilot randomized controlled trial (RCT) assessed the effect of NPWT on SSI and other wound complications in obese women undergoing elective caesarean sections (CS) and also the feasibility of conducting a definitive trial. Ninety-two obese women undergoing elective CS were randomized in theatre via a central web based system using a parallel 1:1 process to two groups i.e., 46 women received the intervention (NPWT PICO™ dressing) and 46 women received standard care (Comfeel Plus® dressing). All women received the intended dressing following wound closure. The relative risk of SSI in the intervention group was 0.81 (95% CI 0.38–1.68); for the number of complications excluding SSI it was 0.98 (95% CI 0.34–2.79). A sample size of 784 (392 per group) would be required to find a statistically significant difference in SSI between the two groups with 90% power. These results demonstrate that a larger definitive trial is feasible and that careful planning and site selection is critical to the success of the overall study.
Keyword Obesity
Surgical site infections
NPWT
Caesarean section
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Nursing, Midwifery and Social Work Publications
 
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Created: Fri, 13 Mar 2015, 11:32:41 EST by Vicki Percival on behalf of School of Nursing, Midwifery and Social Work