Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii isolates in the Gulf Cooperation Council states: Dominance of OXA-23-type producers

Zowawi, Hosam M., Sartor, Anna L., Sidjabat, Hanna E., Balkhy, Hanan H., Walsh, Timothy R., Al Johani, Sameera M., Aljindan, Reem Y., Alfaresi, Mubarak, Ibrahim, Emad, Al-Jardani, Amina, Al Salman, Jameela, Dashti, Ali A., Johani, Khalid and Paterson, David L. (2015) Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii isolates in the Gulf Cooperation Council states: Dominance of OXA-23-type producers. Journal of Clinical Microbiology, 53 3: 896-903. doi:10.1128/JCM.02784-14

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Author Zowawi, Hosam M.
Sartor, Anna L.
Sidjabat, Hanna E.
Balkhy, Hanan H.
Walsh, Timothy R.
Al Johani, Sameera M.
Aljindan, Reem Y.
Alfaresi, Mubarak
Ibrahim, Emad
Al-Jardani, Amina
Al Salman, Jameela
Dashti, Ali A.
Johani, Khalid
Paterson, David L.
Title Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii isolates in the Gulf Cooperation Council states: Dominance of OXA-23-type producers
Journal name Journal of Clinical Microbiology   Check publisher's open access policy
ISSN 0095-1137
1098-660X
Publication date 2015-03-01
Year available 2015
Sub-type Article (original research)
DOI 10.1128/JCM.02784-14
Open Access Status File (Publisher version)
Volume 53
Issue 3
Start page 896
End page 903
Total pages 8
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Collection year 2016
Language eng
Formatted abstract
The molecular epidemiology and mechanisms of resistance of carbapenem-resistant Acinetobacter baumannii (CRAB) were determined in hospitals in the states of the Cooperation Council for the Arab States of the Gulf (Gulf Cooperation Council [GCC]), namely, Saudi Arabia, United Arab Emirates, Oman, Qatar, Bahrain, and Kuwait. Isolates were subjected to PCR-based detection of antibiotic resistance genes and repetitive sequence-based PCR (rep-PCR) assessments of clonality. Selected isolates were subjected to multilocus sequence typing (MLST). We investigated 117 isolates resistant to carbapenem antibiotics (either imipenem or meropenem). All isolates were positive for OXA-51. The most common carbapenemases were the OXA-23-type, found in 107 isolates, followed by OXA-40-type (OXA-24-type), found in 5 isolates; 3 isolates carried the ISAba1 element upstream of blaOXA-51-type. No OXA-58-type, NDM-type, VIM-type, or IMP-type producers were detected. Multiple clones were detected with 16 clusters of clonally related CRAB. Some clusters involved hospitals in different states. MLST analysis of 15 representative isolates from different clusters identified seven different sequence types (ST195, ST208, ST229, ST436, ST450, ST452, and ST499), as well as three novel STs. The vast majority (84%) of the isolates in this study were associated with health care exposure. Awareness of multidrug-resistant organisms in GCC states has important implications for optimizing infection control practices; establishing antimicrobial stewardship programs within hospital, community, and agricultural settings; and emphasizing the need for establishing regional active surveillance systems. This will help to control the spread of CRAB in the Middle East and in hospitals accommodating transferred patients from this region.
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Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2016 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 14 times in Scopus Article | Citations
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