Brief report: intestinal dysbiosis in ankylosing spondylitis

Costello, Mary-Ellen, Ciccia, Francesco, Willner, Dana, Warrington, Nicole, Robinson, Philip C., Gardiner, Brooke, Marshall, Mhairi, Kenna, Tony J., Triolo. Giovanni and Brown, Matthew A. (2015) Brief report: intestinal dysbiosis in ankylosing spondylitis. Arthritis and Rheumatology, 67 3: 686-691. doi:10.1002/art.38967

Author Costello, Mary-Ellen
Ciccia, Francesco
Willner, Dana
Warrington, Nicole
Robinson, Philip C.
Gardiner, Brooke
Marshall, Mhairi
Kenna, Tony J.
Triolo. Giovanni
Brown, Matthew A.
Title Brief report: intestinal dysbiosis in ankylosing spondylitis
Journal name Arthritis and Rheumatology   Check publisher's open access policy
ISSN 2326-5205
Publication date 2015-03-01
Year available 2015
Sub-type Article (original research)
DOI 10.1002/art.38967
Open Access Status
Volume 67
Issue 3
Start page 686
End page 691
Total pages 6
Place of publication Hoboken NJ, United States
Publisher John Wiley & Sons
Collection year 2016
Language eng
Formatted abstract
Ankylosing spondylitis (AS) is a common, highly heritable immune-mediated arthropathy that occurs in genetically susceptible individuals exposed to an unknown but likely ubiquitous environmental trigger. There is a close relationship between the gut and spondyloarthritis, as exemplified in patients with reactive arthritis, in whom a typically self-limiting arthropathy follows either a gastrointestinal or urogenital infection. Microbial involvement in AS has been suggested; however, no definitive link has been established. The aim of this study was to determine whether the gut in patients with AS carries a distinct microbial signature compared with that in the gut of healthy control subjects.

Microbial profiles for terminal ileum biopsy specimens obtained from patients with recent-onset tumor necrosis factor antagonist–naive AS and from healthy control subjects were generated using culture-independent 16S ribosomal RNA gene sequencing and analysis techniques.

Our results showed that the terminal ileum microbial communities in patients with AS differ significantly (P < 0.001) from those in healthy control subjects, driven by a higher abundance of 5 families of bacteria (Lachnospiraceae [P = 0.001], Ruminococcaceae [P = 0.012], Rikenellaceae [P = 0.004], Porphyromonadaceae [P = 0.001], and Bacteroidaceae [P = 0.001]) and a decrease in the abundance of 2 families of bacteria (Veillonellaceae [P = 0.01] and Prevotellaceae [P = 0.004]).

We show evidence for a discrete microbial signature in the terminal ileum of patients with AS compared with healthy control subjects. The microbial composition was demonstrated to correlate with disease status, and greater differences were observed between disease groups than within disease groups. These results are consistent with the hypothesis that genes associated with AS act, at least in part, through effects on the gut microbiome.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Australian Centre for Ecogenomics
Official 2016 Collection
UQ Diamantina Institute Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 22 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 10 Mar 2015, 00:52:50 EST by System User on behalf of UQ Diamantina Institute