PSMA-targeting iron oxide magnetic nanoparticles enhance MRI of preclinical prostate cancer

Tse, Brian Wan-Chi, Cowin, Gary J, Soekmadji, Carolina, Jovanovic, Lidija, Vasireddy, Raja S, Ling, Ming-Tat, Khatri, Aparajita, Liu, Tianqing, Thierry, Benjamin and Russell, Pamela J (2015) PSMA-targeting iron oxide magnetic nanoparticles enhance MRI of preclinical prostate cancer. Nanomedicine, 10 3: 375-386. doi:10.2217/nnm.14.122


Author Tse, Brian Wan-Chi
Cowin, Gary J
Soekmadji, Carolina
Jovanovic, Lidija
Vasireddy, Raja S
Ling, Ming-Tat
Khatri, Aparajita
Liu, Tianqing
Thierry, Benjamin
Russell, Pamela J
Title PSMA-targeting iron oxide magnetic nanoparticles enhance MRI of preclinical prostate cancer
Journal name Nanomedicine   Check publisher's open access policy
ISSN 1748-6963
1743-5889
Publication date 2015
Sub-type Article (original research)
DOI 10.2217/nnm.14.122
Volume 10
Issue 3
Start page 375
End page 386
Total pages 12
Place of publication London, United Kingdom
Publisher Future Medicine Ltd
Collection year 2016
Language eng
Formatted abstract
Aim: To evaluate the potential of newly-developed, biocompatible iron oxide magnetic nanoparticles (MNPs) conjugated with J591, an antibody to an extracellular epitope of PSMA, to enhance MRI of prostate cancer.

Materials & methods: Specific binding to PSMA by J591-MNP was investigated in vitro. MRI studies were performed on orthotopic tumor-bearing NOD.SCID mice 2 h and 24 h after intravenous injection of J591-MNPs, or non-targeting MNPs.

Results & conclusion: In vitro, MNPs did not affect prostate cancer cell viability, and conjugation to J591 did not compromise antibody specificity and enhanced cellular iron uptake. Magnetic resonance contrast of tumors was increased in vivo using PSMA-targeting MNPs, but not by non-targeting MNPs. This provides proof-of-concept that PSMA-targeting MNPs have potential to enhance magnetic resonance detection/localization of prostate cancer.
Keyword cancer imaging
iron oxide magnetic nanoparticles (MNPs)
MRI
prostate cancer
prostate specific membrane antigen (PSMA)
targeted imaging
targeted nanoparticles
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
Centre for Advanced Imaging Publications
 
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