The burden of selected congenital anomalies amenable to surgery in low and middle-income regions: cleft lip and palate, congenital heart anomalies and neural tube defects

Higashi, Hideki, Barendregt, Jan J., Kassebaum, Nicholas J., Weiser, Thomas G., Bickler, Stephen W. and Vos, Theo (2015) The burden of selected congenital anomalies amenable to surgery in low and middle-income regions: cleft lip and palate, congenital heart anomalies and neural tube defects. Archives of Disease in Childhood, 100 3: 233-238. doi:10.1136/archdischild-2014-306175


Author Higashi, Hideki
Barendregt, Jan J.
Kassebaum, Nicholas J.
Weiser, Thomas G.
Bickler, Stephen W.
Vos, Theo
Title The burden of selected congenital anomalies amenable to surgery in low and middle-income regions: cleft lip and palate, congenital heart anomalies and neural tube defects
Journal name Archives of Disease in Childhood   Check publisher's open access policy
ISSN 1468-2044
0003-9888
Publication date 2015-03-01
Year available 2014
Sub-type Article (original research)
DOI 10.1136/archdischild-2014-306175
Open Access Status
Volume 100
Issue 3
Start page 233
End page 238
Total pages 6
Place of publication London, United Kingdom
Publisher BMJ Publishing Group
Collection year 2015
Language eng
Formatted abstract
Objective To quantify the burden of selected congenital anomalies in low and middle-income countries (LMICs) that could be reduced should surgical programmes cover the entire population with access to quality care.

Design Burden of disease and epidemiological modelling.

Setting LMICs from all global regions.

Population All prevalent cases of selected congenital anomalies at birth in 2010.

Main outcome measures
Disability-adjusted life years (DALYs).

Interventions and methods Surgical programmes for three congenital conditions were analysed: clefts (lip and palate); congenital heart anomalies; and neural tube defects. Data from the Global Burden of Disease 2010 Study were used to estimate the combination of fatal burden that could be addressed by surgical care and the additional long-term non-fatal burden associated with increased survival.

Results Of the estimated 21.6 million DALYs caused by these three conditions in LMICs, 12.4 million DALYs (57%) are potentially addressable by surgical care among the population born with such conditions. Neural tube defects have the largest potential with 76% of burden amenable by surgery, followed by clefts (59%) and congenital heart anomalies (49%). Sub-Saharan Africa and South Asia have the greatest proportion of surgically addressable burden for clefts (68%), North Africa and Middle East for congenital heart anomalies (73%), and South Asia for neural tube defects (81%).

Conclusions There is an important and neglected role surgical programmes can play in reducing the burden of congenital anomalies in LMICs.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 26 Sep 2014

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Public Health Publications
 
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