The feasibility of an exercise intervention in males at risk of oesophageal adenocarcinoma: A randomized controlled trial

Winzer, Brooke M., Paratz, Jennifer D., Whitehead, Jonathan P., Whiteman, David C. and Reeves, Marina M. (2015) The feasibility of an exercise intervention in males at risk of oesophageal adenocarcinoma: A randomized controlled trial. PLoS One, 10 2: 1-17. doi:10.1371/journal.pone.0117922


Author Winzer, Brooke M.
Paratz, Jennifer D.
Whitehead, Jonathan P.
Whiteman, David C.
Reeves, Marina M.
Title The feasibility of an exercise intervention in males at risk of oesophageal adenocarcinoma: A randomized controlled trial
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2015-02-23
Year available 2015
Sub-type Article (original research)
DOI 10.1371/journal.pone.0117922
Open Access Status DOI
Volume 10
Issue 2
Start page 1
End page 17
Total pages 17
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Collection year 2015
Language eng
Formatted abstract
Objective
To investigate the feasibility and safety of a 24-week exercise intervention, compared to control, in males with Barrett’s oesophagus, and to estimate the effect of the intervention, compared to control, on risk factors associated with oesophageal adenocarcinoma development.

Methods
A randomized controlled trial of an exercise intervention (60 minutes moderate-intensity aerobic and resistance exercise five days/week over 24 weeks; one supervised and four unsupervised sessions) versus attention control (45 minutes stretching five days/week over 24 weeks; one supervised and four unsupervised sessions) in inactive, overweight/obese (25.0–34.9 kg/m2) males with Barrett’s oesophagus, aged 18–70 years. Primary outcomes were obesity-associated hormones relevant to oesophageal adenocarcinoma risk (circulating concentrations of leptin, adiponectin, interleukin-6, tumour necrosis factor-alpha, C-reactive protein, and insulin resistance [HOMA]). Secondary outcomes included waist circumference, body composition, fitness, strength and gastro-oesophageal reflux symptoms. Outcomes were measured at baseline and 24-weeks. Intervention effects were analysed using generalised linear models, adjusting for baseline value.

Results
Recruitment was difficult in this population with a total of 33 participants recruited (target sample size: n = 80); 97% retention at 24-weeks. Adherence to the exercise protocol was moderate. No serious adverse events were reported. A statistically significant intervention effect (exercise minus control) was observed for waist circumference (-4.5 [95% CI -7.5, -1.4] cm; p < 0.01). Effects on primary outcomes were not statistically significant.

Conclusion
This small, exploratory trial provides important information to inform future trial development including recruitment rates and estimates of effect sizes on outcomes related to oesophageal adenocarcinoma risk. Future trials should investigate a combined dietary and exercise intervention to achieve greater weight loss in this population and relax inclusion criteria to maximize recruitment.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
Official 2016 Collection
School of Public Health Publications
School of Medicine Publications
 
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