A H-1 MRS study of probable Alzheimer's disease and normal aging: Implications for longitudinal monitoring of dementia progression

Rose, S. E., De Zubicaray, G. I., Wang, D., Galloway, G. J., Chalk, J. B., Semple, J., Eagle, S. C. and Doddrell, D. M. (1999) A H-1 MRS study of probable Alzheimer's disease and normal aging: Implications for longitudinal monitoring of dementia progression. Magnetic Resonance Imaging, 17 2: 291-299.


Author Rose, S. E.
De Zubicaray, G. I.
Wang, D.
Galloway, G. J.
Chalk, J. B.
Semple, J.
Eagle, S. C.
Doddrell, D. M.
Title A H-1 MRS study of probable Alzheimer's disease and normal aging: Implications for longitudinal monitoring of dementia progression
Journal name Magnetic Resonance Imaging   Check publisher's open access policy
ISSN 0730-725X
Publication date 1999-02
Sub-type Article (original research)
DOI 10.1016/S0730-725X(98)00168-4
Volume 17
Issue 2
Start page 291
End page 299
Total pages 9
Place of publication Oxford
Publisher Elsevier Science Inc.
Language eng
Subject C1
730100 Clinical (Organs, Diseases and Abnormal Conditions)
321022 Radiology and Organ Imaging
Abstract In order to evaluate the capability of H-1 MRS to monitor longitudinal changes in subjects with probable Alzheimer's disease (AD), the temporal stability of the metabolite measures N-acetylaspartate and N-acetylas-partylglutamate (NA), total Creatine (Cr), myo-Inositol (mI), total Choline (Chol), NA/Cr, mI/Cr, Chol/Cr and NA/mI were investigated in a cohort of normal older adults. Only the metabolite measures NA, mi, Cr, NA/Cr, mI/Cr, and NA/mI were found to be stable after a mean interval of 260 days. Relative and absolute metabolite measures from a cohort of patients with probable AD were subsequently compared with data from a sample of normal older adult control subjects, and correlated with mental status and the degree of atrophy in the localized voxel. Concentrations of NA, NA/Cr, and NA/mI were significantly reduced in the AD group with concomitant significant increases in mi and mI/Cr. There were no differences between the two groups in measures of Cr, Chol, or Chol/Cr. Significant correlations between mental status as measured by the Mini-Mental State Examination and NA/mI, mI/Cr and NA were found. These metabolite measures were also significantly correlated with the extent of atrophy (as measured by CSF and GM composition) in the spectroscopy voxel. (C) 1999 Elsevier Science Inc.
Keyword Radiology, Nuclear Medicine & Medical Imaging
Alzheimer's Disease
Magnetic Resonance Spectroscopy
Magnetic-resonance Spectroscopy
Human Brain
Metabolite Concentrations
Choline
Invivo
Myoinositol
Aspartate
Creatine
Spectra
Water
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
 
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