Oxidative stress contributes to muscle atrophy in chronic kidney disease patients

Beetham, Kassia S., Howden, Erin J., Small, David M., Briskey, David R., Rossi, Megan, Isbel, Nicole and Coombes, Jeff S. (2015) Oxidative stress contributes to muscle atrophy in chronic kidney disease patients. Redox Report, 20 3: 126-132. doi:10.1179/1351000214Y.0000000114

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Author Beetham, Kassia S.
Howden, Erin J.
Small, David M.
Briskey, David R.
Rossi, Megan
Isbel, Nicole
Coombes, Jeff S.
Title Oxidative stress contributes to muscle atrophy in chronic kidney disease patients
Journal name Redox Report   Check publisher's open access policy
ISSN 1743-2928
Publication date 2015
Sub-type Article (original research)
DOI 10.1179/1351000214Y.0000000114
Volume 20
Issue 3
Start page 126
End page 132
Total pages 7
Place of publication Leeds, United Kingdom
Publisher Maney Publishing
Collection year 2016
Language eng
Formatted abstract
Objectives: Patients with chronic kidney disease have impaired muscle metabolism, resulting in muscle atrophy. Oxidative stress has previously been identified as a significant contributor to muscle atrophy in other populations, but the contribution in chronic kidney disease is unknown. The aim of this study was to investigate the association between oxidative stress, grip strength, and lean mass in patients with chronic kidney disease.

Methods: This is a cross-sectional study of 152 participants with stage 3 or 4 chronic kidney disease. Outcome measures include grip strength, lean mass, plasma total F2-isoprostanes, inflammation, peak oxygen uptake, and standard clinical measures.

Results: Thirty four (22.4%) chronic kidney disease patients had elevated oxidative stress levels (plasma F2-isoprostanes >250 pg/ml), with 82% of patients below age-predicted grip strength normative values. There was a significant negative association between plasma F2-isoprostanes and grip strength (r = −0.251) and lean mass (r = −0.243). There were no associations with inflammation markers. Multiple linear regression identified plasma F2-isoprostanes as a significant predictor of grip strength independent of other predictors: sex, diabetes status, body mass index, body fat percent, and phosphate (adjusted r 2 = 69.5, P < 0.001).

Discussion: Plasma F2-isoprostanes were independently associated with reduced strength in chronic kidney disease patients
Keyword Oxidative stress
Muscular atrophy
Muscle strength
Kidney diseases
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Human Movement and Nutrition Sciences Publications
School of Medicine Publications
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Created: Mon, 09 Mar 2015, 15:21:32 EST by Sandrine Ducrot on behalf of School of Human Movement and Nutrition Sciences