Retinal microvessels reflect familial vulnerability to psychotic symptoms: A comparison of twins discordant for psychotic symptoms and controls

Meier, Madeline H., Gillespie, Nathan A., Hansell, Narelle K., Hewitt, Alex W., Hickie, Ian B., Lu, Yi, McGrath, John, MacGregor, Stuart, Medland, Sarah E., Sun, Cong, Wong, Tien Y., Wright, Margaret J., Zhu, Gu, Martin, Nicholas G. and Mackey, David A. (2015) Retinal microvessels reflect familial vulnerability to psychotic symptoms: A comparison of twins discordant for psychotic symptoms and controls. Schizophrenia Research, 164 1-3: 47-52. doi:10.1016/j.schres.2015.01.045


Author Meier, Madeline H.
Gillespie, Nathan A.
Hansell, Narelle K.
Hewitt, Alex W.
Hickie, Ian B.
Lu, Yi
McGrath, John
MacGregor, Stuart
Medland, Sarah E.
Sun, Cong
Wong, Tien Y.
Wright, Margaret J.
Zhu, Gu
Martin, Nicholas G.
Mackey, David A.
Title Retinal microvessels reflect familial vulnerability to psychotic symptoms: A comparison of twins discordant for psychotic symptoms and controls
Journal name Schizophrenia Research   Check publisher's open access policy
ISSN 1573-2509
0920-9964
Publication date 2015-05
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.schres.2015.01.045
Volume 164
Issue 1-3
Start page 47
End page 52
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2016
Language eng
Abstract Mounting evidence suggests that individuals with schizophrenia have an underlying vulnerability to cardiovascular disease, and a recent study suggested that this vulnerability might be reflected in the retinal microvasculature. The purpose of this study was to test the hypothesis that the retinal microvessels reflect familial vulnerability to psychotic symptoms. Participants were 531 adolescent and young adult twins who took part in the Brisbane Longitudinal Twin Study and the Twins Eye Study in Tasmania. The twins had photographs taken of their retina when they were adolescents or young adults (M age = 20.6 years), and retinal vessel diameter was assessed using computer software. The twins completed an assessment of psychosis symptoms approximately six years later. We compared retinal venular diameters of individuals with one or more symptoms of psychosis (n = 45), their unaffected co-twins (n = 24), and controls (n = 462). Individuals with one or more symptoms of psychosis had wider venules (standardized mean = 0.29) than controls (standardized mean = − 0.04; p = .03), and unaffected co-twins had venular diameters that were intermediate (standardized mean = 0.13) between the two groups, suggesting that wide venules may represent a proxy marker of familial vulnerability to psychosis symptoms. Consistent with previous work, there were no differences in arteriolar diameter between individuals with and without symptoms of psychosis. Findings suggest that wide retinal venules may serve as a proxy marker of familial liability to psychosis symptoms. The pathophysiological mechanisms linking psychosis and cardiovascular disease may be operative from early in life, possibly at the level of the microvasculature.
Keyword Psychosis
Retinal vessel diameter
Twin
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
School of Medicine Publications
 
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