Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis

Bowes, John, Budu-Aggrey, Ashley, Huffmeier, Ulrike, Uebe, Steffen, Steel, Kathryn, Hebert, Harry L., Wallace, Chris, Massey, Jonathan, Bruce, Ian N., Bluett, James, Feletar, Marie, Morgan, Ann W., Marzo-Ortega, Helena, Donohoe, Gary, Morris, Derek W., Helliwell, Philip, Ryan, Anthony W., Kane, David, Warren, Richard B., Korendowych, Eleanor, Alenius, Gerd-Marie, Giardina, Emiliano, Packham, Jonathan, McManus, Ross, Fitzgerald, Oliver, McHugh, Neil, Brown, Matthew A., Ho, Pauline, Behrens, Frank, Burkhardt, Harald, Reis, Andre and Barton, Anne (2015) Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis. Nature Communications, 6 Art No.: 6046: . doi:10.1038/ncomms7046

Author Bowes, John
Budu-Aggrey, Ashley
Huffmeier, Ulrike
Uebe, Steffen
Steel, Kathryn
Hebert, Harry L.
Wallace, Chris
Massey, Jonathan
Bruce, Ian N.
Bluett, James
Feletar, Marie
Morgan, Ann W.
Marzo-Ortega, Helena
Donohoe, Gary
Morris, Derek W.
Helliwell, Philip
Ryan, Anthony W.
Kane, David
Warren, Richard B.
Korendowych, Eleanor
Alenius, Gerd-Marie
Giardina, Emiliano
Packham, Jonathan
McManus, Ross
Fitzgerald, Oliver
McHugh, Neil
Brown, Matthew A.
Ho, Pauline
Behrens, Frank
Burkhardt, Harald
Reis, Andre
Barton, Anne
Title Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis
Journal name Nature Communications   Check publisher's open access policy
ISSN 2041-1723
Publication date 2015
Year available 2015
Sub-type Article (original research)
DOI 10.1038/ncomms7046
Open Access Status DOI
Volume 6
Issue Art No.: 6046
Total pages 10
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
soriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis and, despite the larger estimated heritability for PsA, the majority of genetic susceptibility loci identified to date are shared with psoriasis. Here, we present results from a case–control association study on 1,962 PsA patients and 8,923 controls using the Immunochip genotyping array. We identify eight loci passing genome-wide significance, secondary independent effects at three loci and a distinct PsA-specific variant at the ‚ÄčIL23R locus. We report two novel loci and evidence of a novel PsA-specific association at chromosome 5q31. Imputation of classical HLA alleles, amino acids and SNPs across the MHC region highlights three independent associations to class I genes. Finally, we find an enrichment of associated variants to markers of open chromatin in CD8+ memory primary T cells. This study identifies key insights into the genetics of PsA that could begin to explain fundamental differences between psoriasis and PsA.
Keyword Biological sciences
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 18 times in Scopus Article | Citations
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