Active Tension: The Role of Cadherin Adhesion and Signaling in Generating Junctional Contractility

Priya, Rashmi and Yap, Alpha S. (2015). Active Tension: The Role of Cadherin Adhesion and Signaling in Generating Junctional Contractility. In Alpha S. Yap (Ed.), Cellular Adhesion in Development and Disease (pp. 65-102) Maryland Heights, MO United States: Academic Press. doi:10.1016/bs.ctdb.2014.11.016


Author Priya, Rashmi
Yap, Alpha S.
Title of chapter Active Tension: The Role of Cadherin Adhesion and Signaling in Generating Junctional Contractility
Title of book Cellular Adhesion in Development and Disease
Place of Publication Maryland Heights, MO United States
Publisher Academic Press
Publication Year 2015
Sub-type Research book chapter (original research)
DOI 10.1016/bs.ctdb.2014.11.016
Year available 2015
Series Current Topics in Developmental Biology
ISBN 9780124077584
ISSN 0070-2153
1557-8933
Editor Alpha S. Yap
Volume number 112
Chapter number 3
Start page 65
End page 102
Total pages 57
Total chapters 14
Collection year 2016
Language eng
Abstract/Summary In this chapter, we discuss the cell biology of contractility at cell–cell junctions. As discussed elsewhere in this volume, contractile forces play key roles in development and tissue homeostasis. Here, we review our understanding of the cellular mechanisms that functionally and physically link cadherin adhesion to the actomyosin contractile apparatus of the cell. Focusing on epithelia, we argue that E-cadherin junctions can be considered as active mechanical agents, which contribute to the assembly of actomyosin at the junctional cortex itself. This reflects cortical signaling, notably that regulated by the Rho GTPase, coordinated with actin regulation at junctions. The product, contractile tension at junctions, can then be regarded as an emergent property of a complex dynamical system that integrates adhesion with the cytoskeleton.
Keyword Actomyosin
Cadherin
Cytoskeleton
Signaling
Q-Index Code B1
Q-Index Status Provisional Code
Institutional Status UQ

 
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