Fasting gut hormone levels change with modest weight loss in obese adolescents

Jensen, D. E., Nguo, K., Baxter, K. A., Cardinal, J. W., King, N. A., Ware, R. S., Truby, H. and Batch, J. A. (2015) Fasting gut hormone levels change with modest weight loss in obese adolescents. Pediatric Obesity, 10 5: 380-387. doi:10.1111/ijpo.275

Author Jensen, D. E.
Nguo, K.
Baxter, K. A.
Cardinal, J. W.
King, N. A.
Ware, R. S.
Truby, H.
Batch, J. A.
Title Fasting gut hormone levels change with modest weight loss in obese adolescents
Journal name Pediatric Obesity   Check publisher's open access policy
ISSN 2047-6310
Publication date 2015
Sub-type Article (original research)
DOI 10.1111/ijpo.275
Volume 10
Issue 5
Start page 380
End page 387
Total pages 8
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2016
Language eng
Formatted abstract
Gut hormones change with weight loss in adults but are not well studied in obese youth.

The primary aim was to evaluate how gut hormones and subjective appetite measure change with dietary weight loss in obese adolescents.

Participants were a subset of those taking part in the ‘Eat Smart Study’. They were aged 10–17 years with body mass index (BMI) > 90th centile and were randomized to one of three groups: wait-listed control, structured reduced carbohydrate or structured low-fat dietary intervention for 12 weeks. Outcomes were fasting glucose, insulin, leptin, adiponectin, total amylin, acylated ghrelin, active glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide (GIP), pancreatic polypeptide (PP) and total peptide tyrosine-tyrosine. Pre- and postprandial subjective sensations of appetite were assessed using visual analogue scales.

Of 87 ‘Eat Smart’ participants, 74 participated in this sub-study. The mean (standard deviation) BMI z-score was 2.1 (0.4) in the intervention groups at week 12 compared with 2.2 (0.4) in the control group. Fasting insulin (P = 0.05) and leptin (P = 0.03) levels decreased, while adiponectin levels increased (P = 0.05) in the intervention groups compared with control. The intervention groups were not significantly different from each other. A decrease in BMI z-score at week 12 was associated with decreased fasting insulin (P < 0.001), homeostatic model of assessment-insulin resistance (P < 0.001), leptin (P < 0.001), total amylin (P = 0.03), GIP (P = 0.01), PP (P = 0.02) and increased adiponectin (P < 0.001). There was no significant difference in appetite sensations.

Modest weight loss in obese adolescents leads to changes in some adipokines and gut hormones that may favour weight regain.
Keyword Adolescent obesity
Gut hormones
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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