Cell-Cell Interactions Driving Kidney Morphogenesis

Combes, Alexander N., Davies, Jamie A. and Little, Melissa H. (2015). Cell-Cell Interactions Driving Kidney Morphogenesis. In Alpha S. Yap (Ed.), Cellular Adhesion in Development and Disease (pp. 467-508) Maryland Heights, MO United States: Academic Press. doi:10.1016/bs.ctdb.2014.12.002

Author Combes, Alexander N.
Davies, Jamie A.
Little, Melissa H.
Title of chapter Cell-Cell Interactions Driving Kidney Morphogenesis
Title of book Cellular Adhesion in Development and Disease
Place of Publication Maryland Heights, MO United States
Publisher Academic Press
Publication Year 2015
Sub-type Research book chapter (original research)
DOI 10.1016/bs.ctdb.2014.12.002
Year available 2015
Series Current Topics in Developmental Biology
ISBN 9780124077584
ISSN 0070-2153
Editor Alpha S. Yap
Volume number 112
Chapter number 14
Start page 467
End page 508
Total pages 42
Total chapters 14
Collection year 2016
Language eng
Formatted Abstract/Summary
The mammalian kidney forms via cell–cell interactions between an epithelial outgrowth of the nephric duct and the surrounding nephrogenic mesenchyme. Initial morphogenetic events include ureteric bud branching to form the collecting duct (CD) tree and mesenchymal-to-epithelial transitions to form the nephrons, requiring reciprocal induction between adjacent mesenchyme and epithelial cells. Within the tips of the branching ureteric epithelium, cells respond to mesenchyme-derived trophic factors by proliferation, migration, and mitosis-associated cell dispersal. Self-inhibition signals from one tip to another play a role in branch patterning. The position, survival, and fate of the nephrogenic mesenchyme are regulated by ECM and secreted signals from adjacent tip and stroma. Signals from the ureteric tip promote mesenchyme self-renewal and trigger nephron formation. Subsequent fusion to the CDs, nephron segmentation and maturation, and formation of a patent glomerular basement membrane also require specialized cell–cell interactions. Differential cadherin, laminin, nectin, and integrin expression, as well as intracellular kinesin and actin-mediated regulation of cell shape and adhesion, underlies these cell–cell interactions. Indeed, the capacity for the kidney to form via self-organization has now been established both via the recapitulation of expected morphogenetic interactions after complete dissociation and reassociation of cellular components during development as well as the in vitro formation of 3D kidney organoids from human pluripotent stem cells. As we understand more about how the many cell–cell interactions required for kidney formation operate, this enables the prospect of bioengineering replacement structures based on these self-organizing properties.
Keyword Cadherin
Cap mesenchyme
Cell cell adhesion
Glomerular basement membrane
Kidney development
Q-Index Code B1
Q-Index Status Provisional Code
Institutional Status UQ

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