Exclusive development of a single type of keratinocyte skin cancer: evidence from an Australian population-based cohort study

Keim, Ulrike, van der Pols, Jolieke C., Williams, Gail M. and Green, Adele C. (2015) Exclusive development of a single type of keratinocyte skin cancer: evidence from an Australian population-based cohort study. Journal of Investigative Dermatology, 135 3: 728-733. doi:10.1038/jid.2014.410


Author Keim, Ulrike
van der Pols, Jolieke C.
Williams, Gail M.
Green, Adele C.
Title Exclusive development of a single type of keratinocyte skin cancer: evidence from an Australian population-based cohort study
Journal name Journal of Investigative Dermatology   Check publisher's open access policy
ISSN 1523-1747
0022-202X
Publication date 2015-03-12
Year available 2014
Sub-type Article (original research)
DOI 10.1038/jid.2014.410
Open Access Status
Volume 135
Issue 3
Start page 728
End page 733
Total pages 6
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2015
Language eng
Abstract Whether susceptible people develop both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) or one type exclusively during life is unknown. We investigated this in an Australian community cohort of 1,191 adults aged 25–75 years by recording all new BCCs and SCCs for 16 years in people with no previous keratinocyte cancer. Among those who developed multiple skin cancers, age- and sex-specific incidence rates per 100,000 were calculated for those who developed BCC exclusively, SCC exclusively, or BCC and SCC. Corresponding relative risks (and 95% confidence intervals) were estimated by Poisson regression. During follow-up, 116 people developed multiple keratinocyte cancers: 65 (56%) developed BCC exclusively (range 2–8 per person); 18 (16%) developed SCC exclusively (2–5 per person); and 28% developed both types. Of the 116, 88 had a BCC first, of whom 74% subsequently developed only BCCs, and 28 had SCC first, of whom 64% subsequently developed only SCCs. Incidence rates did not differ by sex in the BCC-only, SCC-only, or mixed groups, but they increased significantly with age especially in the SCC-only group. These findings suggest that the majority of people are prone to develop one type rather than a mix of keratinocyte cancers.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 16 Oct 2014

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Public Health Publications
 
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