Active contractility at E-cadherin junctions and its implications for cell extrusion in cancer

Wu, Selwin K., Lagendijk, Anne K., Hogan, Benjamin M., Gomez, Guillermo A. and Yap, Alpha S. (2015) Active contractility at E-cadherin junctions and its implications for cell extrusion in cancer. Cell Cycle, 14 3: 315-322. doi:10.4161/15384101.2014.989127


Author Wu, Selwin K.
Lagendijk, Anne K.
Hogan, Benjamin M.
Gomez, Guillermo A.
Yap, Alpha S.
Title Active contractility at E-cadherin junctions and its implications for cell extrusion in cancer
Journal name Cell Cycle   Check publisher's open access policy
ISSN 1551-4005
1538-4101
Publication date 2015-02-06
Year available 2015
Sub-type Article (original research)
DOI 10.4161/15384101.2014.989127
Open Access Status
Volume 14
Issue 3
Start page 315
End page 322
Total pages 8
Place of publication Austin, TX United States
Publisher Landes Bioscience
Collection year 2016
Language eng
Abstract Cellular contractility regulates tissue cohesion and morphogenesis. In epithelia, E-cadherin adhesion couples the contractile cortices of neighboring cells together to produce tension at junctions that can be transmitted across the epithelium in a planar fashion. We have recently demonstrated that contractility is also patterned in the apical-lateral axis within epithelial junctions. Our findings highlight the role that cytoskeletal regulation plays in controlling the levels of intra-junctional tension. Of note, dysregulation of this apicolateral pattern of tension can drive oncogenic cell extrusion. In this article, we provide a detailed description of the actomyosin cytoskeleton organization during oncogenic extrusion and discuss the implications of cell extrusion in cancer.
Keyword Actin
Cell extrusion
E-cadherin
Myosin
Oncogene
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 2 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 03 Mar 2015, 00:30:12 EST by System User on behalf of Institute for Molecular Bioscience