Alterations in white matter fractional anisotropy in subsyndromal perimenopausal depression

Wang, Xianglan, Tao, Jiong, Li, Lingjiang, Zhong, Zhiyong, Liu, Sha, Jiang, Tianzi and Zhang, Jinbei (2014) Alterations in white matter fractional anisotropy in subsyndromal perimenopausal depression. BMC Psychiatry, 14 1: . doi:10.1186/s12888-014-0367-8


Author Wang, Xianglan
Tao, Jiong
Li, Lingjiang
Zhong, Zhiyong
Liu, Sha
Jiang, Tianzi
Zhang, Jinbei
Title Alterations in white matter fractional anisotropy in subsyndromal perimenopausal depression
Journal name BMC Psychiatry   Check publisher's open access policy
ISSN 1471-244X
Publication date 2014-12
Year available 2014
Sub-type Article (original research)
DOI 10.1186/s12888-014-0367-8
Open Access Status DOI
Volume 14
Issue 1
Total pages 8
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2015
Language eng
Formatted abstract
Background
Subsyndromal depression (SSD) is considered as a predictor for future depressive disorders, however whether white matter abnormalities are involved in the high-susceptibility of women to depressive disorders during perimenopause is unknown. The purpose of this study was to investigate fractional anisotropy (FA) in the white matter of the whole brain in perimenopausal women with SSD using diffusion tensor imaging (DTI).

Methods
In a cross-sectional study, 24 perimenopausal women with SSD and 24 other age-, education-, and body mass index-matched healthy women underwent DTI. A voxel-based analysis was used to elucidate regional FA changes at a voxel threshold of p < 0.001 with an extent threshold of k > 127 voxels (p < 0.05, AlphaSim correction). Subsequently, correlation analyses were performed between mean FA values in significant brain regions and plasma estradiol level.

Results
Compared to healthy controls, women with SSD exhibited significantly lower FA values in the left insula, while higher FA values were observed in the left ventral lateral thalamus and left and right brainstem in the midbrain. In subjects with SSD, the mean FA value in the left insula was positively correlated to plasma estradiol levels (r = 0.453, p = 0.026) (uncorrected).

Conclusions
Our findings indicate altered microstructures in white matter of the insula and subcortical regions may be associated with the high susceptibility of perimenopausal women to depressive disorders. Estrogen may modulate the white matter microstructure of the insula.
Keyword White matter
Fractional anisotropy
Estrogen
Perimenopause
Depressive disorders
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article no. 14:367

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
 
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Created: Mon, 02 Mar 2015, 14:00:42 EST by Susan Day on behalf of Queensland Brain Institute