Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study

Gottlieb, D. J., Hek, K., Chen, T. H., Watson, N. F., Eiriksdottir, G., Byrne, E. M., Cornelis, M., Warby, S. C., Bandinelli, S., Cherkas, L., Evans, D. S., Grabe, H. J., Lahti, J., Li, M., Lehtimaki, T., Lumley, T., Marciante, K. D., Perusse, L., Psaty, B. M., Robbins, J., Tranah, G. J., Vink, J. M., Wilk, J. B., Stafford, J. M., Bellis, C., Biffar, R., Bouchard, C., Cade, B., Curhan, G. C., Eriksson, J. G., Ewert, R., Ferrucci, L., Fulop, T., Gehrman, P. R., Goodloe, R., Harris, B., Heath, A. C., Hernandez, D., Hofman, A., Hottenga, J.-J., Hunter, D. J., Jensen, M. K., Johnson, A. D., Kahonen, M., Kao, L., Kraft, P., Larkin, E. K., Lauderdale, D. S., Luik, A. I., Medici, M., Montgomery, G. W., Palotie, A., Patel, S. R., Pistis, G., Porcu, E., Quaye, L., Raitakari, O., Redline, S., Rimm, E. B., Rotter, J. I., Smith, A. V., Spector, T. D., Teumer, A., Uitterlinden, A. G., Vohl, M.-C., Widen, E., Willemsen, G., Young, T., Zhang, X., Liu, Y., Blangero, J., Boomsma, D. I., Gudnason, V., Hu, F., Mangino, M., Martin, N. G., O'Connor, G. T., Stone, K. L., Tanaka, T., Viikari, J., Gharib, S. A., Punjabi, N. M., Raikkonen, K., Volzke, H., Mignot, E. and Tiemeier, H. (2014) Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study. Molecular Psychiatry, 20 10: 1232-1239. doi:10.1038/mp.2014.133

Author Gottlieb, D. J.
Hek, K.
Chen, T. H.
Watson, N. F.
Eiriksdottir, G.
Byrne, E. M.
Cornelis, M.
Warby, S. C.
Bandinelli, S.
Cherkas, L.
Evans, D. S.
Grabe, H. J.
Lahti, J.
Li, M.
Lehtimaki, T.
Lumley, T.
Marciante, K. D.
Perusse, L.
Psaty, B. M.
Robbins, J.
Tranah, G. J.
Vink, J. M.
Wilk, J. B.
Stafford, J. M.
Bellis, C.
Biffar, R.
Bouchard, C.
Cade, B.
Curhan, G. C.
Eriksson, J. G.
Ewert, R.
Ferrucci, L.
Fulop, T.
Gehrman, P. R.
Goodloe, R.
Harris, B.
Heath, A. C.
Hernandez, D.
Hofman, A.
Hottenga, J.-J.
Hunter, D. J.
Jensen, M. K.
Johnson, A. D.
Kahonen, M.
Kao, L.
Kraft, P.
Larkin, E. K.
Lauderdale, D. S.
Luik, A. I.
Medici, M.
Montgomery, G. W.
Palotie, A.
Patel, S. R.
Pistis, G.
Porcu, E.
Quaye, L.
Raitakari, O.
Redline, S.
Rimm, E. B.
Rotter, J. I.
Smith, A. V.
Spector, T. D.
Teumer, A.
Uitterlinden, A. G.
Vohl, M.-C.
Widen, E.
Willemsen, G.
Young, T.
Zhang, X.
Liu, Y.
Blangero, J.
Boomsma, D. I.
Gudnason, V.
Hu, F.
Mangino, M.
Martin, N. G.
O'Connor, G. T.
Stone, K. L.
Tanaka, T.
Viikari, J.
Gharib, S. A.
Punjabi, N. M.
Raikkonen, K.
Volzke, H.
Mignot, E.
Tiemeier, H.
Title Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study
Journal name Molecular Psychiatry   Check publisher's open access policy
ISSN 1476-5578
Publication date 2014-12-02
Year available 2014
Sub-type Article (original research)
DOI 10.1038/mp.2014.133
Open Access Status
Volume 20
Issue 10
Start page 1232
End page 1239
Total pages 8
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2015
Language eng
Formatted abstract
Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide association study (GWAS) of usual sleep duration was conducted using 18 population-based cohorts totaling 47 180 individuals of European ancestry. Genome-wide significant association was identified at two loci. The strongest is located on chromosome 2, in an intergenic region 35- to 80-kb upstream from the thyroid-specific transcription factor PAX8 (lowest P=1.1 × 10−9). This finding was replicated in an African-American sample of 4771 individuals (lowest P=9.3 × 10−4). The strongest combined association was at rs1823125 (P=1.5 × 10−10, minor allele frequency 0.26 in the discovery sample, 0.12 in the replication sample), with each copy of the minor allele associated with a sleep duration 3.1 min longer per night. The alleles associated with longer sleep duration were associated in previous GWAS with a more favorable metabolic profile and a lower risk of attention deficit hyperactivity disorder. Understanding the mechanisms underlying these associations may help elucidate biological mechanisms influencing sleep duration and its association with psychiatric, metabolic and cardiovascular disease.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 2 Dec 2014

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 4 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 02 Mar 2015, 13:14:18 EST by Susan Day on behalf of Queensland Brain Institute