Vaginal type-II mucosa is an inductive site for primary CD8+ T-cell mucosal immunity

Wang, Yichuan, Sui, Yongjun, Kato, Shingo, Hogg, Alison E., Steel, Jason C., Morris, John C. and Berzofsky, Jay A. (2015) Vaginal type-II mucosa is an inductive site for primary CD8+ T-cell mucosal immunity. Nature Communications, 6 6100: 1-13. doi:10.1038/ncomms7100

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Author Wang, Yichuan
Sui, Yongjun
Kato, Shingo
Hogg, Alison E.
Steel, Jason C.
Morris, John C.
Berzofsky, Jay A.
Title Vaginal type-II mucosa is an inductive site for primary CD8+ T-cell mucosal immunity
Journal name Nature Communications   Check publisher's open access policy
ISSN 2041-1723
Publication date 2015-01-20
Year available 2015
Sub-type Article (original research)
DOI 10.1038/ncomms7100
Open Access Status File (Publisher version)
Volume 6
Issue 6100
Start page 1
End page 13
Total pages 13
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2016
Language eng
Formatted abstract
The structured lymphoid tissues are considered the only inductive sites where primary T-cell immune responses occur. The naïve T cells in structured lymphoid tissues, once being primed by antigen-bearing dendritic cells, differentiate into memory T cells and traffic back to the mucosal sites through the bloodstream. Contrary to this belief, here we show that the vaginal type-II mucosa itself, despite the lack of structured lymphoid tissues, can act as an inductive site during primary CD8+ T-cell immune responses. We provide evidence that the vaginal mucosa supports both the local immune priming of naïve CD8+ T cells and the local expansion of antigen-specific CD8+ T cells, thereby demonstrating a different paradigm for primary mucosal T-cell immune induction.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
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