Outcomes following surgery and post-operative radiotherapy for perineural spread of head and neck cutaneous squamous cell carcinoma

Warren, Timothy A., Panizza, Benedict, Porceddu, Sandro V., Gandhi, Mitesh, Patel, Parag, Wood, Martin, Nagle, Christina M. and Redmond, Michael (2015) Outcomes following surgery and post-operative radiotherapy for perineural spread of head and neck cutaneous squamous cell carcinoma. Head and Neck, 38 6: 824-831. doi:10.1002/hed.23982

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Author Warren, Timothy A.
Panizza, Benedict
Porceddu, Sandro V.
Gandhi, Mitesh
Patel, Parag
Wood, Martin
Nagle, Christina M.
Redmond, Michael
Title Outcomes following surgery and post-operative radiotherapy for perineural spread of head and neck cutaneous squamous cell carcinoma
Journal name Head and Neck   Check publisher's open access policy
ISSN 1043-3074
1097-0347
Publication date 2015-05-06
Sub-type Article (original research)
DOI 10.1002/hed.23982
Volume 38
Issue 6
Start page 824
End page 831
Total pages 8
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2016
Language eng
Formatted abstract
Background: Queensland, Australia has the highest rates of cutaneous squamous cell carcinoma (SCC). Perineural invasion (PNI) is associated with reduced local control and survival.

Methods: A retrospective review of a prospective database of patients with clinical PNI from cutaneous SCC of the head and neck (CSCCHN) treated with surgery and post-operative radiotherapy between 2000-2011 and a minimum of 24 months follow-up. Patients were excluded if immunosuppressed, had non-SCC histology or treated palliatively.

Results: 50 patients (mean age 60 years) with median follow-up of 50 months were included. 54.8% of known primary tumors had incidental PNI. 10% had nodal disease at presentation. MR neurogram was positive in 95.8%. Recurrence-free survival at 5-years was 62%. 5-year disease-specific survival and overall survival were 75% and 64%, respectively. There were no peri-operative deaths.

Conclusion: This report demonstrates that long-term survival is achievable in patients with clinical PNI from CSCCHN following surgery and post-operative radiotherapy. This article is protected by copyright. All rights reserved.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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Created: Fri, 27 Feb 2015, 18:48:48 EST by Dr Benedict Panizza on behalf of Surgery - Princess Alexandra Hospital