Uterine artery pulsatility index assessment at 11-13(+6) weeks' gestation

Ridding, Gus, Schluter, Phillip J., Hyett, Jon A. and McLennan, Andrew C. (2014) Uterine artery pulsatility index assessment at 11-13(+6) weeks' gestation. Fetal Diagnosis and Therapy, 36 4: 299-304. doi:10.1159/000361021

Author Ridding, Gus
Schluter, Phillip J.
Hyett, Jon A.
McLennan, Andrew C.
Title Uterine artery pulsatility index assessment at 11-13(+6) weeks' gestation
Formatted title
Uterine artery pulsatility index assessment at 11–13+6 weeks’ gestation
Journal name Fetal Diagnosis and Therapy   Check publisher's open access policy
ISSN 1015-3837
Publication date 2014-12
Sub-type Article (original research)
DOI 10.1159/000361021
Open Access Status
Volume 36
Issue 4
Start page 299
End page 304
Total pages 6
Place of publication Basel, Switzerland
Publisher S. Karger
Collection year 2015
Language eng
Formatted abstract
Introduction: First-trimester uterine artery pulsatility index (PI) measurements form part of an algorithm used to assess the risk of developing pre-eclampsia. The objective of this study was to construct a population-specific reference range for both the lower and mean maternal uterine artery PI at 11-13+6 weeks' gestation and to assess measurement agreement.

Materials and Methods: Reference ranges for mean and lower PI measurements were developed using polynomial regression models following prospective collection of maternal uterine artery PI measurements at 11-13+6 weeks' gestation. Measurement agreement studies were performed by two experienced operators.

Results: Measurements from 298 women were included in the primary study. Polynomial regression indicated no change over gestational age for the lower PI (mean 1.44). There was an inverse relationship between the average PI and gestational age (mean [0.8960 + (2.9771 × CRL-1/2)]2). PI measurement agreement was good-strong (intraclass correlation (ICC) 0.50-0.79) between operators, and within-operator agreement was almost perfect (ICC 0.88-0.93).

Conclusions: Reference ranges for both the average and lowest PI of the maternal uterine arteries were derived at 11-13+6 weeks' gestation. This will provide a basis for development of auditable standards for first-trimester uterine artery Doppler measurements. The PI measurements are reproducible and reliable.
Keyword Uterine artery Doppler
First trimester
Reference range

Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Nursing, Midwifery and Social Work Publications
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Created: Thu, 26 Feb 2015, 09:04:26 EST by Vicki Percival on behalf of School of Nursing, Midwifery and Social Work