Role of IL-17 and IL-22 in autoimmunity and cancer

Blake, S. J. and Teng, M. W. L. (2014) Role of IL-17 and IL-22 in autoimmunity and cancer. Actas Dermo-Sifiliograficas, 105 Suppl.1: 41-50. doi:10.1016/S0001-7310(14)70017-1


Author Blake, S. J.
Teng, M. W. L.
Title Role of IL-17 and IL-22 in autoimmunity and cancer
Journal name Actas Dermo-Sifiliograficas   Check publisher's open access policy
ISSN 1578-2190
0001-7310
Publication date 2014-10
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S0001-7310(14)70017-1
Open Access Status
Volume 105
Issue Suppl.1
Start page 41
End page 50
Total pages 10
Place of publication Madrid, Spain
Publisher Elsevier Doyma
Collection year 2015
Language eng
Formatted abstract
The dysregulation of inflammatory cytokines can cause a variety of diseases, such as autoimmunity and cancer. Since their identification in 2005, Th17 cells and its signature cytokine IL-17, have been implicated in the pathogenesis of autoimmune diseases such as psoriasis and rheumatoid arthritis (RA), and inflammatory associated cancers such as colorectal carcinoma (CRC). Recently, IL-22 a Th17 related cytokine has been shown to be pathogenic in psoriasis and RA. In this review, we will summarize the biological functions of IL-17 and IL-22, their role in autoimmune diseases and briefly review results from clinical trials targeting IL-17 or its receptor for the treatment of autoimmune diseases. Next, we will discuss pre-clinical and clinical data supporting the rationale of targeting other cytokines implicated in the Th17/IL-17 pathway, such as IL-22 and IL-23. Finally, we discuss the role of IL-17, and in particularly IL-22 in tumour immunity and possible therapeutic interventions.
Keyword Autoimmunity
Cancer
IL-22
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
School of Medicine Publications
 
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