Lessons learnt in the management of primary invasive penile cancer in an Australian tertiary referral centre: Clinical outcomes with a minimum 48 months follow-up study

Chung, Eric, Yang, Sun, White, Louise, Wood, Simon and Nicol, David (2015) Lessons learnt in the management of primary invasive penile cancer in an Australian tertiary referral centre: Clinical outcomes with a minimum 48 months follow-up study. Korean Journal of Urology, 56 2: 125-130. doi:10.4111/kju.2015.56.2.125


Author Chung, Eric
Yang, Sun
White, Louise
Wood, Simon
Nicol, David
Title Lessons learnt in the management of primary invasive penile cancer in an Australian tertiary referral centre: Clinical outcomes with a minimum 48 months follow-up study
Journal name Korean Journal of Urology   Check publisher's open access policy
ISSN 2005-6745
2005-6737
Publication date 2015-02-01
Year available 2015
Sub-type Article (original research)
DOI 10.4111/kju.2015.56.2.125
Volume 56
Issue 2
Start page 125
End page 130
Total pages 6
Place of publication Seoul, Republic of Korea
Publisher Korean Urological Association
Collection year 2016
Formatted abstract
Purpose
To report on lessons learnt in the management of primary invasive penile cancer in a major tertiary hospital in Australia.

Materials and Methods
Medical records for all patients who underwent surgery for primary invasive penile cancer between January 2000 and January 2011 were obtained. Patient demographics, clinical status of inguinal node, cancer stage and clinical outcomes were reviewed. All patients were followed up for a minimum of 48 months postoperative unless patient deceased within the first 48 months from the time of penile cancer surgery.

Results
Over the 11-year period, a total of 23 cases of invasive penile cancer were identified. Partial penectomy was the most common form of organ preserving surgery and the majority of patients have pT1b disease. Of the 9 patients with clinically palpable inguinal nodes, 7 patients were diagnosed with pN3 disease following inguinal lymphadenectomy. The Kaplan-Meier cancer-specific survival at 72 months showed decreasing survival based on tumour stage (83% in pT1, 79% in pT2, and 64% in pT3 disease) and nodal disease (100% in node negative, 50% in superficial inguinal lymphadenopathy, and 38% in patients with deep inguinal and/or pelvic lymphadenopathy) (p=0.082). The Kaplan-Meier cancer-specific survival revealed statistically significant difference in survival outcome in patients with local recurrence vs. systemic metastasis disease (33% vs. 17%, p=0.008).

Conclusions
The presence of high risk features such as tumour stage, lymph node involvement and distant metastasis carries a significant higher risk of death and tumour recurrence in patients with penile cancer and inguinal lymph node metastasis.
Keyword Penile neoplasms
Survival
Treatment outcome
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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