Can mass drug administration lead to the sustainable control of schistosomiasis?

Ross, Allen G. P., Olveda, Remigio M., Chy, Delia, Olveda, David U., Li, Yuesheng, Harn, Donald A., Gray, Darren J., McManus, Donald P., Tallo, Veronica, Chau, Thao N. P. and Williams, Gail M. (2015) Can mass drug administration lead to the sustainable control of schistosomiasis?. Journal of Infectious Diseases, 211 2: 283-289. doi:10.1093/infdis/jiu416


Author Ross, Allen G. P.
Olveda, Remigio M.
Chy, Delia
Olveda, David U.
Li, Yuesheng
Harn, Donald A.
Gray, Darren J.
McManus, Donald P.
Tallo, Veronica
Chau, Thao N. P.
Williams, Gail M.
Title Can mass drug administration lead to the sustainable control of schistosomiasis?
Journal name Journal of Infectious Diseases   Check publisher's open access policy
ISSN 1537-6613
0022-1899
Publication date 2015-01-15
Year available 2014
Sub-type Article (original research)
DOI 10.1093/infdis/jiu416
Open Access Status
Volume 211
Issue 2
Start page 283
End page 289
Total pages 7
Place of publication Cary, NC United States
Publisher Oxford University Press
Collection year 2015
Language eng
Formatted abstract
Background In the Philippines, the current national control strategy for schistosomiasis is annual mass drug administration (MDA) with 40 mg/kg of praziquantel in all schistosomiasis-endemic villages with a prevalence ≥10%.

Methods A cross-sectional survey of schistosomiasis was conducted in 2012 on 18 221 individuals residing in 22 schistosomiasis-endemic villages in the province of Northern Samar. The prevalence of schistosomiasis, intensity of Schistosoma infection, and morbidity of disease were assessed.

Results Despite an active schistosomiasis-control program in Northern Samar for >30 years, which included a MDA campaign in the last 5 years, the mean prevalence of schistosomiasis among 10 435 evaluated subjects was 27.1% (95% confidence interval [CI], 26.3%–28.0%), and the geometric mean intensity of infection among 2832 evaluated subjects was 17.2 eggs per gram of feces (95% CI, 16.4–18.1). Ultrasonography revealed high levels of schistosomiasis-induced morbidity in the schistosomiasis-endemic communities. Left lobe liver enlargement (≥70 mm) was evident in 89.3% of subjects. Twenty-five percent of the study population had grade II/III liver parenchyma fibrosis, and 13.3% had splenomegaly (≥100 mm).

Conclusions MDA on its own was insufficient to control the prevalence of schistosomiasis, intensity of Schistosoma infection, or morbidity of the disease. Alternative control measures will be needed to complement the existing national MDA program.
Keyword Schistosomiasis
Mass drug administration (MDA)
Control
Elimination
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 28 July 2014

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Public Health Publications
 
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