Malathion-induced testicular toxicity is associated with spermatogenic apoptosis and alterations in testicular enzymes and hormone levels in male Wistar rats

Geng, Xiao, Shao, Hua, Zhang, Zhihu, Ng, Jack C. and Peng, Cheng (2015) Malathion-induced testicular toxicity is associated with spermatogenic apoptosis and alterations in testicular enzymes and hormone levels in male Wistar rats. Environmental Toxicology and Pharmacology, 39 2: 659-667. doi:10.1016/j.etap.2015.01.010

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Author Geng, Xiao
Shao, Hua
Zhang, Zhihu
Ng, Jack C.
Peng, Cheng
Title Malathion-induced testicular toxicity is associated with spermatogenic apoptosis and alterations in testicular enzymes and hormone levels in male Wistar rats
Journal name Environmental Toxicology and Pharmacology   Check publisher's open access policy
ISSN 1872-7077
1382-6689
Publication date 2015-03-01
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.etap.2015.01.010
Open Access Status File (Author Post-print)
Volume 39
Issue 2
Start page 659
End page 667
Total pages 9
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2016
Language eng
Abstract Malathion has a broad range of toxicities while its reproductive effects have not been fully elucidated. In this study, we treated animals with malathion by gavage at doses of 0, 33.75, 54, and 108 mg/kg for 60 days and evaluated the alterations in histology, biochemistry and serology. Malathion caused the reduction in the sperm counts and motility. The reduced body and testis weights were coupled with mild to severe degenerative changes in seminiferous tubules. We found malathion at 54 mg/kg increased spermatogenic apoptosis rate which was confirmed by changes in protein expression of Bax and Bcl-2. The activities of testicular enzymes including ACP, LDH and γ-GT were significantly altered with the reduced level of reproductive hormones such as LH, FSH and T. These results indicate that malathion can elicit deleterious effects on reproductive system of rats. The abnormal levels of hormones and apoptotic proteins induced by malathion may play important roles.
Keyword Malathion
Reproductive effects
Histopathological changes
Testicular enzymes
Apoptosis
Reproductive hormones
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
National Research Centre for Environmental Toxicology Publications
 
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