Inhibitory effects of children's toothpastes and fluoride compounds on Streptococcus mutans, Streptococcus sanguinis and Lactobacillus acidophilus

Evans, Alana, Leishman, Shaneen J., Walsh, Laurence J. and Seow, Wan Kim (2015) Inhibitory effects of children's toothpastes and fluoride compounds on Streptococcus mutans, Streptococcus sanguinis and Lactobacillus acidophilus. European Archives of Paediatric Dentistry, 16 2: 219-226. doi:10.1007/s40368-014-0159-3


Author Evans, Alana
Leishman, Shaneen J.
Walsh, Laurence J.
Seow, Wan Kim
Title Inhibitory effects of children's toothpastes and fluoride compounds on Streptococcus mutans, Streptococcus sanguinis and Lactobacillus acidophilus
Formatted title
Inhibitory effects of children's toothpastes and fluoride compounds on Streptococcus mutans, Streptococcus sanguinis and Lactobacillus acidophilus
Journal name European Archives of Paediatric Dentistry   Check publisher's open access policy
ISSN 1996-9805
1818-6300
Publication date 2015-04
Year available 2014
Sub-type Article (original research)
DOI 10.1007/s40368-014-0159-3
Open Access Status
Volume 16
Issue 2
Start page 219
End page 226
Total pages 8
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2015
Language eng
Formatted abstract
Aim

As suppression of Streptococcus mutans in young children may prevent or delay colonisation of the oral cavity, toothbrushing with dentifrices containing anti-S. mutans activity may aid in preventing caries. The aims of this study were to compare the effects of children’s dentifrices on the growth of S. mutans and non-mutans bacteria (Streptococcus sanguinis and Lactobacillus acidophilus).

Materials and methods

The agar diffusion assay at neutral pH was used to examine the antibacterial activity of commercial dentifrices and their major constituents.

Results

Dentifrices containing 1,450 ppm fluoride produced greater growth inhibition of both S. mutans and S. sanguinis than those with <500 ppm. No inhibition was seen for pure solutions of sodium fluoride or sodium monofluorophosphate at fluoride concentrations up to 100,000 ppm. Stannous fluoride exerted antibacterial effects at concentrations above 10,000 ppm. Significant growth inhibition of both S. mutans and S. sanguinis was seen with sodium lauryl sulphate at 2,500 ppm and with triclosan at 100 ppm. No inhibitory effects were seen for xylitol, sorbitol, sodium pyrophosphate or polyethylene glycol at concentrations up to 80,000 ppm.

Conclusion

Sodium lauryl sulphate is the major bacterial inhibitory compound in children’s dentifrices.
Keyword Children's dentrifices
Streptococcus mutans
Sodium lauryl sulphate
Treoclosan
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes PMID: 25403148 Published online ahead of print 18 Nov 2014

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Dentistry Publications
 
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Created: Wed, 18 Feb 2015, 16:37:04 EST by Professor Laurence Walsh on behalf of School of Dentistry