Hereditary mutations and cancer management in when cancer crosses disciplines

Trainer, Alison H. and Ward, Robyn (2010). Hereditary mutations and cancer management in when cancer crosses disciplines. In Monica Robotin, Ian Olver and Afaf Girgis (Ed.), When cancer crosses disciplines a physicians handbook (pp. 981-1004) London United Kingdom: Imperial College Press. doi:10.1142/9781848163652_0041


Author Trainer, Alison H.
Ward, Robyn
Title of chapter Hereditary mutations and cancer management in when cancer crosses disciplines
Title of book When cancer crosses disciplines a physicians handbook
Place of Publication London United Kingdom
Publisher Imperial College Press
Publication Year 2010
Sub-type Research book chapter (original research)
DOI 10.1142/9781848163652_0041
Open Access Status
ISBN 978-1-84816-364-5
978-1-908978-48-6
Editor Monica Robotin
Ian Olver
Afaf Girgis
Chapter number 41
Start page 981
End page 1004
Total pages 24
Total chapters 48
Language eng
Formatted Abstract/Summary
Over the last decade, our capacity to dissect out and identify different tissue-specific tumour subtypes has greatly expanded. The ability to classify tumours on their molecular and biochemical characteristics has already delivered improved prognostic models for some common tumours like breast cancers. The development of sophisticated tumour classification systems is a first step towards developing treatments which are tailored at the patient-specific level — so-called personalised medicine.

In addition, our ability to identify the small population of tumours that have arisen due to a familial genetic predisposition has fundamentally altered our approach to the identification and management of these cases. In the future, it is anticipated that germline testing for cancer pre-disposition mutations will be routinely performed in some individuals at the time of their initial diagnosis in order to estimate their risk of tumour recurrence and predict their response to therapy. In this scenario, germline genetic testing would move from the domain of a family cancer clinic to the routine clinical setting.
Q-Index Code B1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Book Chapter
Collection: Office of the Vice-Chancellor
 
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Created: Tue, 17 Feb 2015, 11:24:33 EST by Ms Kate Rowe on behalf of Office of Deputy Vice-Chancellor (Research)