The genetic architecture of pediatric cognitive abilities in the Philadelphia Neurodevelopmental Cohort

Robinson, E. B., Kirby, A., Ruparel, K., Yang, J., McGrath, L., Anttila, V., Neale, B. M., Merikangas, K., Lehner, T., Sleiman, P. M. A., Daly, M. J., Gur, R., Gur, R. and Hakonarson, H. (2014) The genetic architecture of pediatric cognitive abilities in the Philadelphia Neurodevelopmental Cohort. Molecular Psychiatry, 20 4: 454-458. doi:10.1038/mp.2014.65


Author Robinson, E. B.
Kirby, A.
Ruparel, K.
Yang, J.
McGrath, L.
Anttila, V.
Neale, B. M.
Merikangas, K.
Lehner, T.
Sleiman, P. M. A.
Daly, M. J.
Gur, R.
Gur, R.
Hakonarson, H.
Title The genetic architecture of pediatric cognitive abilities in the Philadelphia Neurodevelopmental Cohort
Journal name Molecular Psychiatry   Check publisher's open access policy
ISSN 1359-4184
1476-5578
Publication date 2014-07-15
Sub-type Article (original research)
DOI 10.1038/mp.2014.65
Open Access Status
Volume 20
Issue 4
Start page 454
End page 458
Total pages 5
Place of publication London, United Kingdom
Publisher Nature Publishing
Collection year 2015
Language eng
Abstract The objective of this analysis was to examine the genetic architecture of diverse cognitive abilities in children and adolescents, including the magnitude of common genetic effects and patterns of shared and unique genetic influences. Subjects included 3689 members of the Philadelphia Neurodevelopmental Cohort, a general population sample comprising those aged 8-21 years who completed an extensive battery of cognitive tests. We used genome-wide complex trait analysis to estimate the SNP-based heritability of each domain, as well as the genetic correlation between all domains that showed significant genetic influence. Several of the individual domains suggested strong influence of common genetic variants (for example, reading ability, h2 g=0.43, P=4e-06; emotion identification, h2 g=0.36, P=1e-05; verbal memory, h2 g=0.24, P=0.005). The genetic correlations highlighted trait domains that are candidates for joint interrogation in future genetic studies (for example, language reasoning and spatial reasoning, r(g)=0.72, P=0.007). These results can be used to structure future genetic and neuropsychiatric investigations of diverse cognitive abilities.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 16 Feb 2015, 12:55:42 EST by Susan Day on behalf of Queensland Brain Institute