A comparison of lipopolysaccharide-induced hepatitis in ethanol-fed Wistar and Lewis rats

Pennington, HL, Wilce, PA and Worrall, S (1998) A comparison of lipopolysaccharide-induced hepatitis in ethanol-fed Wistar and Lewis rats. Alcoholism-clinical And Experimental Research, 22 7: 1525-1530.


Author Pennington, HL
Wilce, PA
Worrall, S
Title A comparison of lipopolysaccharide-induced hepatitis in ethanol-fed Wistar and Lewis rats
Journal name Alcoholism-clinical And Experimental Research   Check publisher's open access policy
ISSN 0145-6008
Publication date 1998
Sub-type Article (original research)
DOI 10.1097/00000374-199810000-00023
Volume 22
Issue 7
Start page 1525
End page 1530
Total pages 6
Language eng
Abstract Elevated concentrations of plasma proinflammatory cytokines have been detected in patients with alcoholic hepatitis (AH) and in a model of lipopolysaccharide-induced hepatitis in ethanol-fed Wistar rats. These cytokines have been implicated in the pathogenesis of the liver damage. Considering the likely involvement of the immune system in AH, and the frequent use of Lewis rats in autoimmune disease models, Lewis rats were examined in the model to determine whether they would more closely mimic the immune status of a chronic alcoholic and be a preferable strain for use in future experiments. Lipopolysaccharide-induced hepatic tumor necrosis factor-cu, interleukin-1 alpha, interleukin-1 beta, and interleukin-6 mRNA expression was examined in both rat strains. The overall pattern of histological (panlobular piecemeal necrosis) and biochemical liver damage (plasma ALT levels), and cytokine expression was similar in both strains. Thus, it would appear that, despite the known susceptibility of Lewis rats to autoimmune phenomena, they do not respond to the experimental regime significantly better than Wistar rats. This study confirms that unknown mediators are contributing to the liver damage seen in this model and possibly in AH.
Keyword Substance Abuse
Wistar Rat
Lewis Rat
Ethanol
Lipopolysaccharide
Cytokines
Tumor-necrosis-factor
Alcoholic Liver-disease
Interleukin-6 Concentrations
Endotoxin
Expression
Diet
Cdna
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Mon, 13 Aug 2007, 10:44:07 EST