Towards a classification of biomarkers of neuropsychiatric disease: from encompass to compass

Davis, J., Maes, M., Andreazza, A., McGrath, J. J., Tye, S. J. and Berk, M. (2015) Towards a classification of biomarkers of neuropsychiatric disease: from encompass to compass. Molecular Psychiatry, 20 2: 152-153. doi:10.1038/mp.2014.139


Author Davis, J.
Maes, M.
Andreazza, A.
McGrath, J. J.
Tye, S. J.
Berk, M.
Title Towards a classification of biomarkers of neuropsychiatric disease: from encompass to compass
Journal name Molecular Psychiatry   Check publisher's open access policy
ISSN 1476-5578
1359-4184
Publication date 2015-02
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/mp.2014.139
Volume 20
Issue 2
Start page 152
End page 153
Total pages 2
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2015
Language eng
Abstract There is currently considerable imprecision in the nosology of biomarkers used in the study of neuropsychiatric disease. The neuropsychiatric field lags behind others such as oncology, wherein, rather than using 'biomarker' as a blanket term for a diverse range of clinical phenomena, biomarkers have been actively classified into separate categories, including prognostic and predictive tests. A similar taxonomy is proposed for neuropsychiatric diseases in which the core biology remains relatively unknown. This paper divides potential biomarkers into those of (1) risk, (2) diagnosis/trait, (3) state or acuity, (4) stage, (5) treatment response and (6) prognosis, and provides illustrative exemplars. Of course, biomarkers rely on available technology and, as we learn more about the neurobiological correlates of neuropsychiatric disorders, we will realize that the classification of biomarkers across these six categories can change, and some markers may fit into more than one category.
Keyword Biomarkers
Neuropsychiatric disease
Risk
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2016 Collection
 
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Created: Mon, 16 Feb 2015, 11:29:32 EST by Susan Day on behalf of Queensland Brain Institute