Basal forebrain atrophy correlates with amyloid beta burden in Alzheimer's disease

Kerbler, Georg M., Fripp, Jürgen, Rowe, Christopher C., Villemagne, Victor L., Salvado, Olivier, Rose, Stephen, Coulson, Elizabeth J. and Alzheimer's Disease Neuroimaging Initiative (2015) Basal forebrain atrophy correlates with amyloid beta burden in Alzheimer's disease. NeuroImage: Clinical, 7 105-113. doi:10.1016/j.nicl.2014.11.015

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Author Kerbler, Georg M.
Fripp, Jürgen
Rowe, Christopher C.
Villemagne, Victor L.
Salvado, Olivier
Rose, Stephen
Coulson, Elizabeth J.
Alzheimer's Disease Neuroimaging Initiative
Total Author Count Override 8
Title Basal forebrain atrophy correlates with amyloid beta burden in Alzheimer's disease
Formatted title
Basal forebrain atrophy correlates with amyloid β burden in Alzheimer's disease
Journal name NeuroImage: Clinical   Check publisher's open access policy
ISSN 2213-1582
Publication date 2015
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.nicl.2014.11.015
Open Access Status DOI
Volume 7
Start page 105
End page 113
Total pages 9
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2015
Language eng
Formatted abstract
Highlights
• The link between amyloid (Aβ) and basal forebrain degeneration in AD is unclear.
• We find that basal forebrain volumes are correlated with neocortical Aβ burden.
• Basal forebrain volume correlates with Aβ burden in at-risk control subjects.
• Basal forebrain atrophy delineates subjects at increased risk of progressing to AD.

The brains of patients suffering from Alzheimer's disease (AD) have three classical pathological hallmarks: amyloid-beta (Aβ) plaques, tau tangles, and neurodegeneration, including that of cholinergic neurons of the basal forebrain. However the relationship between Aβ burden and basal forebrain degeneration has not been extensively studied. To investigate this association, basal forebrain volumes were determined from magnetic resonance images of controls, subjects with amnestic mild cognitive impairment (aMCI) and AD patients enrolled in the longitudinal Alzheimer's Disease Neuroimaging Initiative (ADNI) and Australian Imaging, Biomarkers and Lifestyle (AIBL) studies. In the AIBL cohort, these volumes were correlated within groups to neocortical gray matter retention of Pittsburgh compound B (PiB) from positron emission tomography images as a measure of Aβ load. The basal forebrain volumes of AD and aMCI subjects were significantly reduced compared to those of control subjects. Anterior basal forebrain volume was significantly correlated to neocortical PiB retention in AD subjects and aMCI subjects with high Aβ burden, whereas posterior basal forebrain volume was significantly correlated to neocortical PiB retention in control subjects with high Aβ burden. Therefore this study provides new evidence for a correlation between neocortical Aβ accumulation and basal forebrain degeneration. In addition, cluster analysis showed that subjects with a whole basal forebrain volume below a determined cut-off value had a 7 times higher risk of having a worse diagnosis within ~18 months.
Keyword Basal forebrain
Amyloid
Alzheimer's disease
Magnetic resonance imaging
PET
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 27 November 2014

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2015 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 16 Feb 2015, 09:52:29 EST by Susan Day on behalf of Queensland Brain Institute