Mechanisms of group A Streptococcus resistance to reactive oxygen species

Henningham, Anna, Döhrmann, Simon, Nizet, Victor and Cole, Jason N. (2015) Mechanisms of group A Streptococcus resistance to reactive oxygen species. FEMS Microbiology Reviews, 39 4: 488-508. doi:10.1093/femsre/fuu009

Author Henningham, Anna
Döhrmann, Simon
Nizet, Victor
Cole, Jason N.
Title Mechanisms of group A Streptococcus resistance to reactive oxygen species
Formatted title
Mechanisms of group A Streptococcus resistance to reactive oxygen species
Journal name FEMS Microbiology Reviews   Check publisher's open access policy
ISSN 1574-6976
Publication date 2015-02-10
Year available 2015
Sub-type Article (original research)
DOI 10.1093/femsre/fuu009
Volume 39
Issue 4
Start page 488
End page 508
Total pages 21
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2016
Language eng
Formatted abstract
Streptococcus pyogenes, also known as group A Streptococcus (GAS), is an exclusively human Gram-positive bacterial pathogen ranked among the ‘top 10’ causes of infection-related deaths worldwide. GAS commonly causes benign and self-limiting epithelial infections (pharyngitis and impetigo), and less frequent severe invasive diseases (bacteremia, toxic shock syndrome and necrotizing fasciitis). Annually, GAS causes 700 million infections, including 1.8 million invasive infections with a mortality rate of 25%. In order to establish an infection, GAS must counteract the oxidative stress conditions generated by the release of reactive oxygen species (ROS) at the infection site by host immune cells such as neutrophils and monocytes. ROS are the highly reactive and toxic byproducts of oxygen metabolism, including hydrogen peroxide (H2O2), superoxide anion (O2), hydroxyl radicals (OH•) and singlet oxygen (O2*), which can damage bacterial nucleic acids, proteins and cell membranes. This review summarizes the enzymatic and regulatory mechanisms utilized by GAS to thwart ROS and survive under conditions of oxidative stress.
Keyword Group A Streptococcus
Innate immunity
Oxidative stress resistance
Reactive oxygen species
Streptococcus pyogenes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 13 Feb 2015, 10:54:45 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences